Nature Communications (Apr 2019)
Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5 −/− mice
- Yan Li,
- Roberto Tinoco,
- Lisa Elmén,
- Igor Segota,
- Yibo Xian,
- Yu Fujita,
- Avinash Sahu,
- Raphy Zarecki,
- Kerrie Marie,
- Yongmei Feng,
- Ali Khateb,
- Dennie T. Frederick,
- Shiri K. Ashkenazi,
- Hyungsoo Kim,
- Eva Guijarro Perez,
- Chi-Ping Day,
- Rafael S. Segura Muñoz,
- Robert Schmaltz,
- Shibu Yooseph,
- Miguel A. Tam,
- Tongwu Zhang,
- Emily Avitan-Hersh,
- Lihi Tzur,
- Shoshana Roizman,
- Ilanit Boyango,
- Gil Bar-Sela,
- Amir Orian,
- Randal J. Kaufman,
- Marcus Bosenberg,
- Colin R. Goding,
- Bas Baaten,
- Mitchell P. Levesque,
- Reinhard Dummer,
- Kevin Brown,
- Glenn Merlino,
- Eytan Ruppin,
- Keith Flaherty,
- Amanda Ramer-Tait,
- Tao Long,
- Scott N. Peterson,
- Linda M. Bradley,
- Ze’ev A. Ronai
Affiliations
- Yan Li
- Sanford Burnham Prebys Medical Discovery Institute
- Roberto Tinoco
- Sanford Burnham Prebys Medical Discovery Institute
- Lisa Elmén
- Sanford Burnham Prebys Medical Discovery Institute
- Igor Segota
- Sanford Burnham Prebys Medical Discovery Institute
- Yibo Xian
- Department of Food Science and Technology, University of Nebraska-Lincoln
- Yu Fujita
- Sanford Burnham Prebys Medical Discovery Institute
- Avinash Sahu
- Center for Bioinformatics and Computational Biology, Department of Computer Science, University of Maryland
- Raphy Zarecki
- School of Computer Sciences and Sackler School of Medicine, Tel Aviv University
- Kerrie Marie
- Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Yongmei Feng
- Sanford Burnham Prebys Medical Discovery Institute
- Ali Khateb
- Technion Integrated Cancer Center, Faculty of Medicine, Technion Israel Institute of Technology
- Dennie T. Frederick
- Division of Medical Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School
- Shiri K. Ashkenazi
- Technion Integrated Cancer Center, Faculty of Medicine, Technion Israel Institute of Technology
- Hyungsoo Kim
- Sanford Burnham Prebys Medical Discovery Institute
- Eva Guijarro Perez
- Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Chi-Ping Day
- Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Rafael S. Segura Muñoz
- Department of Food Science and Technology, University of Nebraska-Lincoln
- Robert Schmaltz
- Department of Food Science and Technology, University of Nebraska-Lincoln
- Shibu Yooseph
- Department of Computer Science, College of Engineering and Computer Science, University of Central Florida
- Miguel A. Tam
- BioLegend
- Tongwu Zhang
- Division of Cancer Epidemiology and Genetics, Laboratory of Translational Genomics, National Cancer Institute
- Emily Avitan-Hersh
- Technion Integrated Cancer Center, Faculty of Medicine, Technion Israel Institute of Technology
- Lihi Tzur
- Departments of Dermatology and Oncology, Rambam Health Care Campus, Technion Faculty of Medicine
- Shoshana Roizman
- Departments of Dermatology and Oncology, Rambam Health Care Campus, Technion Faculty of Medicine
- Ilanit Boyango
- Departments of Dermatology and Oncology, Rambam Health Care Campus, Technion Faculty of Medicine
- Gil Bar-Sela
- Technion Integrated Cancer Center, Faculty of Medicine, Technion Israel Institute of Technology
- Amir Orian
- Technion Integrated Cancer Center, Faculty of Medicine, Technion Israel Institute of Technology
- Randal J. Kaufman
- Sanford Burnham Prebys Medical Discovery Institute
- Marcus Bosenberg
- Department of Pathology, Yale University
- Colin R. Goding
- Ludwig Institute for Cancer Research, Nuffield Department of Medicine, Old Road Campus, Unviversity of Oxford, Headington
- Bas Baaten
- Sanford Burnham Prebys Medical Discovery Institute
- Mitchell P. Levesque
- Department of Dermatology, University Hospital of Zurich and University of Zurich
- Reinhard Dummer
- Department of Dermatology, University Hospital of Zurich and University of Zurich
- Kevin Brown
- Division of Cancer Epidemiology and Genetics, Laboratory of Translational Genomics, National Cancer Institute
- Glenn Merlino
- Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Eytan Ruppin
- Center for Bioinformatics and Computational Biology, Department of Computer Science, University of Maryland
- Keith Flaherty
- Division of Medical Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School
- Amanda Ramer-Tait
- Department of Food Science and Technology, University of Nebraska-Lincoln
- Tao Long
- Sanford Burnham Prebys Medical Discovery Institute
- Scott N. Peterson
- Sanford Burnham Prebys Medical Discovery Institute
- Linda M. Bradley
- Sanford Burnham Prebys Medical Discovery Institute
- Ze’ev A. Ronai
- Sanford Burnham Prebys Medical Discovery Institute
- DOI
- https://doi.org/10.1038/s41467-019-09525-y
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
RNF5 is a ubiquitin ligase regulating ER stress response. Here the authors show that Rnf5 deficiency potentiates immune response against melanoma via altered microbiota, and isolate bacterial strains that confer the same phenotype to wild type mice.
