Apoptosis-inducing anti-HER2 agents operate through oligomerization-induced receptor immobilization

Jakob C. Stüber; Christian P. Richter; Junel Sotolongo Bellón; Martin Schwill; Iwo König; Benjamin Schuler; Jacob Piehler; Andreas Plückthun

doi:10.1038/s42003-021-02253-4

Communications Biology (Jun 2021)

Apoptosis-inducing anti-HER2 agents operate through oligomerization-induced receptor immobilization

Jakob C. Stüber,
Christian P. Richter,
Junel Sotolongo Bellón,
Martin Schwill,
Iwo König,
Benjamin Schuler,
Jacob Piehler,
Andreas Plückthun

Affiliations

Jakob C. Stüber: Department of Biochemistry, University of Zurich
Christian P. Richter: Department of Biology/Chemistry and Center for Cellular Nanoanalytics, Osnabrück University
Junel Sotolongo Bellón: Department of Biology/Chemistry and Center for Cellular Nanoanalytics, Osnabrück University
Martin Schwill: Department of Biochemistry, University of Zurich
Iwo König: Department of Biochemistry, University of Zurich
Benjamin Schuler: Department of Biochemistry, University of Zurich
Jacob Piehler: Department of Biology/Chemistry and Center for Cellular Nanoanalytics, Osnabrück University
Andreas Plückthun: Department of Biochemistry, University of Zurich

DOI: https://doi.org/10.1038/s42003-021-02253-4
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 12

Abstract

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Stüber et. al. show that receptor tyrosine kinase signaling can be neutralized through intermolecular, biparatopic bipDARPin crosslinking that locks down the bipDARPin-HER2 complexes. This affects the spatiotemporal organization and dynamics of HER2 in the plasma membrane.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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