Nature Communications (Oct 2018)
Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure
- Seitaro Nomura,
- Masahiro Satoh,
- Takanori Fujita,
- Tomoaki Higo,
- Tomokazu Sumida,
- Toshiyuki Ko,
- Toshihiro Yamaguchi,
- Takashige Tobita,
- Atsuhiko T. Naito,
- Masamichi Ito,
- Kanna Fujita,
- Mutsuo Harada,
- Haruhiro Toko,
- Yoshio Kobayashi,
- Kaoru Ito,
- Eiki Takimoto,
- Hiroshi Akazawa,
- Hiroyuki Morita,
- Hiroyuki Aburatani,
- Issei Komuro
Affiliations
- Seitaro Nomura
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Masahiro Satoh
- Genome Science Division, Research Center for Advanced Science and Technologies, The University of Tokyo
- Takanori Fujita
- Genome Science Division, Research Center for Advanced Science and Technologies, The University of Tokyo
- Tomoaki Higo
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
- Tomokazu Sumida
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Toshiyuki Ko
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Toshihiro Yamaguchi
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Takashige Tobita
- Department of Cardiology, Tokyo Women’s Medical University
- Atsuhiko T. Naito
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Masamichi Ito
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Kanna Fujita
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Mutsuo Harada
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Haruhiro Toko
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Yoshio Kobayashi
- Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine
- Kaoru Ito
- Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences
- Eiki Takimoto
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Hiroshi Akazawa
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Hiroyuki Morita
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Hiroyuki Aburatani
- Genome Science Division, Research Center for Advanced Science and Technologies, The University of Tokyo
- Issei Komuro
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- DOI
- https://doi.org/10.1038/s41467-018-06639-7
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 17
Abstract
The mechanisms underlying the transition from cardiac hypertrophy to heart failure following pressure overload are incompletely understood. Here the authors identify the gene programs encoding the morphological and functional characteristics of cardiomyocytes during the transition from early hypertrophy to heart failure via single-cell transcriptomics, establishing a key role for p53 signalling.
