tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis

Aaron M. Savage; Sathishkumar Kurusamy; Yan Chen; Zhen Jiang; Karishma Chhabria; Ryan B. MacDonald; Hyejeong R. Kim; Heather L. Wilson; Fredericus J. M. van Eeden; Angel L. Armesilla; Timothy J. A. Chico; Robert N. Wilkinson

doi:10.1038/s41467-019-08590-7

Nature Communications (Feb 2019)

tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis

Aaron M. Savage,
Sathishkumar Kurusamy,
Yan Chen,
Zhen Jiang,
Karishma Chhabria,
Ryan B. MacDonald,
Hyejeong R. Kim,
Heather L. Wilson,
Fredericus J. M. van Eeden,
Angel L. Armesilla,
Timothy J. A. Chico,
Robert N. Wilkinson

Affiliations

Aaron M. Savage: Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield
Sathishkumar Kurusamy: Cardiovascular Molecular Pharmacology Laboratory, Faculty of Science and Engineering, Research Institute in Healthcare Science, School of Pharmacy, University of Wolverhampton
Yan Chen: Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield
Zhen Jiang: Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield
Karishma Chhabria: Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield
Ryan B. MacDonald: Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield
Hyejeong R. Kim: The Bateson Centre, University of Sheffield
Heather L. Wilson: Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield
Fredericus J. M. van Eeden: The Bateson Centre, University of Sheffield
Angel L. Armesilla: Cardiovascular Molecular Pharmacology Laboratory, Faculty of Science and Engineering, Research Institute in Healthcare Science, School of Pharmacy, University of Wolverhampton
Timothy J. A. Chico: Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield
Robert N. Wilkinson: Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield

DOI: https://doi.org/10.1038/s41467-019-08590-7
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

Read online

Calcium signalling downstream of VEGF is essential for VEGF-induced angiogenesis. Here Savage et al. show that Transmembrane Protein 33 (TMEM33) is required for angiogenesis and the endothelial calcium response to VEGF, revealing a function for TMEM33 in multicellular organisms.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal