NeuroImage: Clinical (Jan 2020)
Biotypes of major depressive disorder: Neuroimaging evidence from resting-state default mode network patterns
- Sugai Liang,
- Wei Deng,
- Xiaojing Li,
- Andrew J. Greenshaw,
- Qiang Wang,
- Mingli Li,
- Xiaohong Ma,
- Tong-Jian Bai,
- Qi-Jing Bo,
- Jun Cao,
- Guan-Mao Chen,
- Wei Chen,
- Chang Cheng,
- Yu-Qi Cheng,
- Xi-Long Cui,
- Jia Duan,
- Yi-Ru Fang,
- Qi-Yong Gong,
- Wen-Bin Guo,
- Zheng-Hua Hou,
- Lan Hu,
- Li Kuang,
- Feng Li,
- Kai-Ming Li,
- Yan-Song Liu,
- Zhe-Ning Liu,
- Yi-Cheng Long,
- Qing-Hua Luo,
- Hua-Qing Meng,
- Dai-Hui Peng,
- Hai-Tang Qiu,
- Jiang Qiu,
- Yue-Di Shen,
- Yu-Shu Shi,
- Tian-Mei Si,
- Chuan-Yue Wang,
- Fei Wang,
- Kai Wang,
- Li Wang,
- Xiang Wang,
- Ying Wang,
- Xiao-Ping Wu,
- Xin-Ran Wu,
- Chun-Ming Xie,
- Guang-Rong Xie,
- Hai-Yan Xie,
- Peng Xie,
- Xiu-Feng Xu,
- Hong Yang,
- Jian Yang,
- Hua Yu,
- Jia-Shu Yao,
- Shu-Qiao Yao,
- Ying-Ying Yin,
- Yong-Gui Yuan,
- Yu-Feng Zang,
- Ai-Xia Zhang,
- Hong Zhang,
- Ke-Rang Zhang,
- Zhi-Jun Zhang,
- Jing-Ping Zhao,
- Ru-Bai Zhou,
- Yi-Ting Zhou,
- Chao-Jie Zou,
- Xi-Nian Zuo,
- Chao-Gan Yan,
- Tao Li
Affiliations
- Sugai Liang
- Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; West China Brain Research Centre, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China
- Wei Deng
- Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; West China Brain Research Centre, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China
- Xiaojing Li
- Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; West China Brain Research Centre, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China
- Andrew J. Greenshaw
- Department of Psychiatry, University of Alberta, Edmonton T6G 2B7, AB, Canada
- Qiang Wang
- Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; West China Brain Research Centre, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China
- Mingli Li
- Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; West China Brain Research Centre, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China
- Xiaohong Ma
- Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; West China Brain Research Centre, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China
- Tong-Jian Bai
- Anhui Medical University, Hefei 230032, Anhui, China
- Qi-Jing Bo
- Beijing Anding Hospital, Capital Medical University, Beijing 100069, China
- Jun Cao
- Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
- Guan-Mao Chen
- The First Affiliated Hospital of Jinan University, Guangzhou 510630, Guangdong, China
- Wei Chen
- Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang, China
- Chang Cheng
- The Second Xiangya Hospital of Central South University, Changsha 410083, Hunan, China
- Yu-Qi Cheng
- First Affiliated Hospital of Kunming Medical University, Kunming 650211, Yunnan, China
- Xi-Long Cui
- The Second Xiangya Hospital of Central South University, Changsha 410083, Hunan, China
- Jia Duan
- Department of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning, China
- Yi-Ru Fang
- Department of Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China
- Qi-Yong Gong
- Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China; Psychoradiology Research Unit of Chinese Academy of Medical Sciences, West China Hospital of Sichuan University, Chengdu 610040, Sichuan, China
- Wen-Bin Guo
- The Second Xiangya Hospital of Central South University, Changsha 410083, Hunan, China
- Zheng-Hua Hou
- Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210096, Jiangsu, China
- Lan Hu
- Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
- Li Kuang
- Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
- Feng Li
- Beijing Anding Hospital, Capital Medical University, Beijing 100069, China
- Kai-Ming Li
- Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China
- Yan-Song Liu
- Department of Clinical Psychology, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou 215031, Jiangsu, China
- Zhe-Ning Liu
- The Institute of Mental Health, Second Xiangya Hospital of Central South University, Changsha 410083, Hunan, China
- Yi-Cheng Long
- Faculty of Psychology, Southwest University, Chongqing 400715, China
- Qing-Hua Luo
- Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
- Hua-Qing Meng
- Department of Clinical Psychology, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou 215031, Jiangsu, China
- Dai-Hui Peng
- Department of Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China
- Hai-Tang Qiu
- Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
- Jiang Qiu
- Faculty of Psychology, Southwest University, Chongqing 400715, China
- Yue-Di Shen
- Department of Diagnostics, Affiliated Hospital, Hangzhou Normal University Medical School, Hangzhou 311121, Zhejiang, China
- Yu-Shu Shi
- Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310058, Zhejiang, China
- Tian-Mei Si
- National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing 100191, China
- Chuan-Yue Wang
- Beijing Anding Hospital, Capital Medical University, Beijing 100069, China
- Fei Wang
- Department of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning, China
- Kai Wang
- Beijing Anding Hospital, Capital Medical University, Beijing 100069, China
- Li Wang
- National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing 100191, China
- Xiang Wang
- Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang, China
- Ying Wang
- The First Affiliated Hospital of Jinan University, Guangzhou 510630, Guangdong, China
- Xiao-Ping Wu
- Xi’an Central Hospital, Xi’an 710032, Shaanxi, China
- Xin-Ran Wu
- Faculty of Psychology, Southwest University, Chongqing 400715, China
- Chun-Ming Xie
- Department of Neurology, Affiliated Zhongda Hospital of Southeast University, Nanjing 210096, Jiangsu, China
- Guang-Rong Xie
- The Second Xiangya Hospital of Central South University, Changsha 410083, Hunan, China
- Hai-Yan Xie
- Department of Psychiatry, The Fourth Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310058, Zhejiang, China
- Peng Xie
- Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China; Chongqing Key Laboratory of Neurobiology, Chongqing 400016, China; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
- Xiu-Feng Xu
- First Affiliated Hospital of Kunming Medical University, Kunming 650211, Yunnan, China
- Hong Yang
- Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310058, Zhejiang, China
- Jian Yang
- The First Affiliated Hospital of Xi’an Jiaotong University, 710049 Shaanxi, China
- Hua Yu
- Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; West China Brain Research Centre, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China
- Jia-Shu Yao
- Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang, China
- Shu-Qiao Yao
- The Second Xiangya Hospital of Central South University, Changsha 410083, Hunan, China
- Ying-Ying Yin
- Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210096, Jiangsu, China
- Yong-Gui Yuan
- Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210096, Jiangsu, China
- Yu-Feng Zang
- Center for Cognition and Brain Disorders, Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou 311121, Zhejiang, China; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou 311121, Zhejiang, China
- Ai-Xia Zhang
- The First Affiliated Hospital of Xi’an Jiaotong University, 710049 Shaanxi, China
- Hong Zhang
- Xi’an Central Hospital, Xi’an 710032, Shaanxi, China
- Ke-Rang Zhang
- First Hospital of Shanxi Medical University, Taiyuan 030607, Shanxi, China
- Zhi-Jun Zhang
- Department of Neurology, Affiliated Zhongda Hospital of Southeast University, Nanjing 210096, Jiangsu, China
- Jing-Ping Zhao
- The Institute of Mental Health, Second Xiangya Hospital of Central South University, Changsha 410083, Hunan, China
- Ru-Bai Zhou
- Department of Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China
- Yi-Ting Zhou
- Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; West China Brain Research Centre, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China
- Chao-Jie Zou
- First Affiliated Hospital of Kunming Medical University, Kunming 650211, Yunnan, China
- Xi-Nian Zuo
- CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing 100101, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100101, China; Magnetic Resonance Imaging Research Center and Research Center for Lifespan Development of Mind and Brain (CLIMB), Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China
- Chao-Gan Yan
- CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing 100101, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100101, China; Magnetic Resonance Imaging Research Center and Research Center for Lifespan Development of Mind and Brain (CLIMB), Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China; Corresponding authors at: CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang District, Beijing 100101, China (C.-G. Yan). Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University; No. 28th Dianxin Nan Str., Chengdu, Sichuan 610041, China (T. Li).
- Tao Li
- Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; West China Brain Research Centre, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; Corresponding authors at: CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang District, Beijing 100101, China (C.-G. Yan). Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University; No. 28th Dianxin Nan Str., Chengdu, Sichuan 610041, China (T. Li).
- Journal volume & issue
-
Vol. 28
p. 102514
Abstract
Background: Major depressive disorder (MDD) is heterogeneous disorder associated with aberrant functional connectivity within the default mode network (DMN). This study focused on data-driven identification and validation of potential DMN-pattern-based MDD subtypes to parse heterogeneity of the disorder. Methods: The sample comprised 1397 participants including 690 patients with MDD and 707 healthy controls (HC) registered from multiple sites based on the REST-meta-MDD Project in China. Baseline resting-state functional magnetic resonance imaging (rs-fMRI) data was recorded for each participant. Discriminative features were selected from DMN between patients and HC. Patient subgroups were defined by K-means and principle component analysis in the multi-site datasets and validated in an independent single-site dataset. Statistical significance of resultant clustering were confirmed. Demographic and clinical variables were compared between identified patient subgroups. Results: Two MDD subgroups with differing functional connectivity profiles of DMN were identified in the multi-site datasets, and relatively stable in different validation samples. The predominant dysfunctional connectivity profiles were detected among superior frontal cortex, ventral medial prefrontal cortex, posterior cingulate cortex and precuneus, whereas one subgroup exhibited increases of connectivity (hyperDMN MDD) and another subgroup showed decreases of connectivity (hypoDMN MDD). The hyperDMN subgroup in the discovery dataset had age-related severity of depressive symptoms. Patient subgroups had comparable demographic and clinical symptom variables. Conclusions: Findings suggest the existence of two neural subtypes of MDD associated with different dysfunctional DMN connectivity patterns, which may provide useful evidence for parsing heterogeneity of depression and be valuable to inform the search for personalized treatment strategies.
