Nature Communications (Oct 2022)

Engineered cell differentiation and sexual reproduction in probiotic and mating yeasts

  • Emil D. Jensen,
  • Marcus Deichmann,
  • Xin Ma,
  • Rikke U. Vilandt,
  • Giovanni Schiesaro,
  • Marie B. Rojek,
  • Bettina Lengger,
  • Line Eliasson,
  • Justin M. Vento,
  • Deniz Durmusoglu,
  • Sandie P. Hovmand,
  • Ibrahim Al’Abri,
  • Jie Zhang,
  • Nathan Crook,
  • Michael K. Jensen

DOI
https://doi.org/10.1038/s41467-022-33961-y
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 15

Abstract

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G protein-coupled receptors (GPCRs) enable cells to sense environmental cues and are indispensable for coordinating vital processes including quorum sensing, proliferation, and sexual reproduction. Here the authors, using heterologous GPCR expression and endogenous ligand production, enable synthetic mating in haploid yeast, and GPCR-mediated biosensing in diploid probiotic yeast.