Competing Genetic Traits and Their Influence on LDL Cholesterol Concentration in Familial Hypercholesterolemia

Christopher Song, MD; Robert S. Rosenson, MD

JACC: Case Reports (Jan 2024)

Competing Genetic Traits and Their Influence on LDL Cholesterol Concentration in Familial Hypercholesterolemia

Christopher Song, MD,
Robert S. Rosenson, MD

Affiliations

Christopher Song, MD: Metabolism and Lipids Program, Mount Sinai Heart, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Robert S. Rosenson, MD: Address for correspondence: Dr Robert S. Rosenson, Icahn School of Medicine at Mount Sinai, Mount Sinai Heart, One Gustave L. Levy Place, Box 1030, New York, New York 10029, USA.; Metabolism and Lipids Program, Mount Sinai Heart, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Journal volume & issue: Vol. 29, no. 2
p. 102171

Abstract

Read online

Familial hypercholesterolemia is a monogenic disorder that leads to premature atherosclerosis as a result of lifelong exposure to elevated low-density lipoprotein cholesterol (LDL-C). Both genetic traits and lifestyle factors can influence LDL-C levels. Adults with LDL-C of 170 mg/dL and higher may benefit from genetic evaluation to accurately assess their risk of atherosclerosis.

Published in JACC: Case Reports

ISSN: 2666-0849 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/jacc-case-reports

About the journal

Abstract

Keywords