mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1

Stéphanie Kaeser-Pebernard; Christine Vionnet; Muriel Mari; Devanarayanan Siva Sankar; Zehan Hu; Carole Roubaty; Esther Martínez-Martínez; Huiyuan Zhao; Miguel Spuch-Calvar; Alke Petri-Fink; Gregor Rainer; Florian Steinberg; Fulvio Reggiori; Jörn Dengjel

doi:10.1038/s41467-022-32487-7

Nature Communications (Aug 2022)

mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1

Stéphanie Kaeser-Pebernard,
Christine Vionnet,
Muriel Mari,
Devanarayanan Siva Sankar,
Zehan Hu,
Carole Roubaty,
Esther Martínez-Martínez,
Huiyuan Zhao,
Miguel Spuch-Calvar,
Alke Petri-Fink,
Gregor Rainer,
Florian Steinberg,
Fulvio Reggiori,
Jörn Dengjel

Affiliations

Stéphanie Kaeser-Pebernard: Department of Biology, University of Fribourg
Christine Vionnet: Department of Biology, University of Fribourg
Muriel Mari: Department of Biomedical Sciences of Cells and Systems, University of Groningen, University Medical Center Groningen
Devanarayanan Siva Sankar: Department of Biology, University of Fribourg
Zehan Hu: Department of Biology, University of Fribourg
Carole Roubaty: Department of Biology, University of Fribourg
Esther Martínez-Martínez: Department of Biology, University of Fribourg
Huiyuan Zhao: Section of Medicine, University of Fribourg
Miguel Spuch-Calvar: Adolf Merkle Institute, University of Fribourg
Alke Petri-Fink: Adolf Merkle Institute, University of Fribourg
Gregor Rainer: Section of Medicine, University of Fribourg
Florian Steinberg: Center for Biological Systems Analysis, University of Freiburg
Fulvio Reggiori: Department of Biomedical Sciences of Cells and Systems, University of Groningen, University Medical Center Groningen
Jörn Dengjel: Department of Biology, University of Fribourg

DOI: https://doi.org/10.1038/s41467-022-32487-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 21

Abstract

Read online

mTORC1 is a master regulator of cell growth with well-known functions in inhibiting autophagic vesicle formation. Here, the authors show that mTORC1 also affects Golgi architecture and vesicle secretion by phosphorylating the scaffold protein SCYL1.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal