Comprehensive B-Cell Immune Repertoire Analysis of Anti-NMDAR Encephalitis and Anti-LGI1 Encephalitis

Jingjing Feng; Jingjing Feng; Siyuan Fan; Yinwei Sun; Yinwei Sun; Haitao Ren; Hongzhi Guan; Jing Wang; Jing Wang

doi:10.3389/fimmu.2021.717598

Frontiers in Immunology (Oct 2021)

Comprehensive B-Cell Immune Repertoire Analysis of Anti-NMDAR Encephalitis and Anti-LGI1 Encephalitis

Jingjing Feng,
Jingjing Feng,
Siyuan Fan,
Yinwei Sun,
Yinwei Sun,
Haitao Ren,
Hongzhi Guan,
Jing Wang,
Jing Wang

Affiliations

Jingjing Feng: CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
Jingjing Feng: Department of Psychology, University of Chinese Academy of Sciences, Beijing, China
Siyuan Fan: Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Yinwei Sun: CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
Yinwei Sun: Department of Psychology, University of Chinese Academy of Sciences, Beijing, China
Haitao Ren: Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Hongzhi Guan: Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Jing Wang: CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
Jing Wang: Department of Psychology, University of Chinese Academy of Sciences, Beijing, China

DOI: https://doi.org/10.3389/fimmu.2021.717598
Journal volume & issue: Vol. 12

Abstract

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Anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDARE) and anti-leucine-rich glioma-inactivated 1 encephalitis (anti-LGI1E) are the two most common types of antibody-mediated autoimmune encephalitis. We performed a comprehensive analysis of the B-cell immune repertoire in patients with anti-NMDARE (n = 7) and anti-LGI1E (n = 10) and healthy controls (n = 4). The results revealed the presence of many common clones between patients with these two types of autoimmune encephalitis, which were mostly class-switched. Additionally, many differences were found among the anti-NMDARE, anti-LGI1E, and healthy control groups, including the diversity of the B-cell immune repertoire and gene usage preference. These findings suggest that the same adaptive immune responses occur in patients with anti-NMDARE and anti-LGI1E, which deserves further exploration.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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Abstract

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