ATP-dependent membrane remodeling links EHD1 functions to endocytic recycling

Raunaq Deo; Manish S. Kushwah; Sukrut C. Kamerkar; Nagesh Y. Kadam; Srishti Dar; Kavita Babu; Anand Srivastava; Thomas J. Pucadyil

doi:10.1038/s41467-018-07586-z

Nature Communications (Dec 2018)

ATP-dependent membrane remodeling links EHD1 functions to endocytic recycling

Raunaq Deo,
Manish S. Kushwah,
Sukrut C. Kamerkar,
Nagesh Y. Kadam,
Srishti Dar,
Kavita Babu,
Anand Srivastava,
Thomas J. Pucadyil

Affiliations

Raunaq Deo: Indian Institute of Science Education and Research
Manish S. Kushwah: Indian Institute of Science Education and Research
Sukrut C. Kamerkar: Indian Institute of Science Education and Research
Nagesh Y. Kadam: Indian Institute of Science Education and Research
Srishti Dar: Indian Institute of Science Education and Research
Kavita Babu: Indian Institute of Science Education and Research
Anand Srivastava: Molecular Biophysics Unit, Indian Institute of Science
Thomas J. Pucadyil: Indian Institute of Science Education and Research

DOI: https://doi.org/10.1038/s41467-018-07586-z
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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The GTPase dynamin catalyzes membrane fission but activity of the dynamin-related ATPase EHD1 is unknown. Here, using in vitro reconstitution assays and molecular dynamics simulations, the authors report that EHD1 hydrolyzes ATP to remodel, causing fission of membrane tubes and that this is necessary for endocytic recycling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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