Nature Communications (Feb 2019)
Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer
- D. Merino,
- T. S. Weber,
- A. Serrano,
- F. Vaillant,
- K. Liu,
- B. Pal,
- L. Di Stefano,
- J. Schreuder,
- D. Lin,
- Y. Chen,
- M. L. Asselin-Labat,
- T. N. Schumacher,
- D. Cameron,
- G. K. Smyth,
- A. T. Papenfuss,
- G. J. Lindeman,
- J. E. Visvader,
- S. H. Naik
Affiliations
- D. Merino
- ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research
- T. S. Weber
- Department of Medical Biology, The University of Melbourne
- A. Serrano
- ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research
- F. Vaillant
- ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research
- K. Liu
- ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research
- B. Pal
- ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research
- L. Di Stefano
- Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research
- J. Schreuder
- Department of Medical Biology, The University of Melbourne
- D. Lin
- Department of Medical Biology, The University of Melbourne
- Y. Chen
- Department of Medical Biology, The University of Melbourne
- M. L. Asselin-Labat
- ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research
- T. N. Schumacher
- Division of Molecular Oncology & Immunology, Netherlands Cancer Institute
- D. Cameron
- Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research
- G. K. Smyth
- Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research
- A. T. Papenfuss
- Department of Medical Biology, The University of Melbourne
- G. J. Lindeman
- ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research
- J. E. Visvader
- ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research
- S. H. Naik
- Department of Medical Biology, The University of Melbourne
- DOI
- https://doi.org/10.1038/s41467-019-08595-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
Triple negative breast cancers (TNBC) disseminate and metastasise, but the clonal relationship of metastases to primary tumours is poorly understood. Here, the authors use cellular barcoding of TNBC patient-derived xenografts and track the fate of barcoded clones in primary tumours and their metastases, including after resection or chemotherapy.
