Nature Communications (Nov 2021)
Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets
- Robert M. Cox,
- Josef D. Wolf,
- Carolin M. Lieber,
- Julien Sourimant,
- Michelle J. Lin,
- Darius Babusis,
- Venice DuPont,
- Julie Chan,
- Kim T. Barrett,
- Diane Lye,
- Rao Kalla,
- Kwon Chun,
- Richard L. Mackman,
- Chengjin Ye,
- Tomas Cihlar,
- Luis Martinez-Sobrido,
- Alexander L. Greninger,
- John P. Bilello,
- Richard K. Plemper
Affiliations
- Robert M. Cox
- Center for Translational Antiviral Research, Institute for Biomedical Sciences, Georgia State University
- Josef D. Wolf
- Center for Translational Antiviral Research, Institute for Biomedical Sciences, Georgia State University
- Carolin M. Lieber
- Center for Translational Antiviral Research, Institute for Biomedical Sciences, Georgia State University
- Julien Sourimant
- Center for Translational Antiviral Research, Institute for Biomedical Sciences, Georgia State University
- Michelle J. Lin
- Virology Division, Department of Laboratory Medicine and Pathology, University of Washington
- Darius Babusis
- Gilead Sciences Inc
- Venice DuPont
- Gilead Sciences Inc
- Julie Chan
- Gilead Sciences Inc
- Kim T. Barrett
- Gilead Sciences Inc
- Diane Lye
- Gilead Sciences Inc
- Rao Kalla
- Gilead Sciences Inc
- Kwon Chun
- Gilead Sciences Inc
- Richard L. Mackman
- Gilead Sciences Inc
- Chengjin Ye
- Texas Biomedical Research Institute
- Tomas Cihlar
- Gilead Sciences Inc
- Luis Martinez-Sobrido
- Texas Biomedical Research Institute
- Alexander L. Greninger
- Virology Division, Department of Laboratory Medicine and Pathology, University of Washington
- John P. Bilello
- Gilead Sciences Inc
- Richard K. Plemper
- Center for Translational Antiviral Research, Institute for Biomedical Sciences, Georgia State University
- DOI
- https://doi.org/10.1038/s41467-021-26760-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
Remdesivir is an approved antiviral treatment for COVID-19, but it needs to be administered intravenously. Here, Cox et al. show that GS-621763, a prodrug of remdesivir parent nucleoside GS-441524 has good oral bioavailability and inhibits SARS-CoV-2 and variants of concerns in ferrets.
