Open Medicine
(Apr 2020)
S100A6 promotes proliferation and migration of HepG2 cells via increased
ubiquitin-dependent degradation of p53
Song Dongqiang,
Xu Beili,
Shi Dongmin,
Li Shuyu,
Cai Yu
Affiliations
Song Dongqiang
Liver Cancer Institute, Department of Hepatic
Oncology, Zhongshan Hospital of Fudan
University,180 Fenglin Road, Xuhui District, Shanghai,
P. R. China
Xu Beili
Department of Gastroenterology and Hepatology,
Zhongshan Hospital of Fudan University, 180
Fenglin Road, Xuhui District,Shanghai, P. R. China
Shi Dongmin
Liver Cancer Institute, Department of Hepatic
Oncology, Zhongshan Hospital of Fudan
University,180 Fenglin Road, Xuhui District, Shanghai,
P. R. China
Li Shuyu
Department of Gastroenterology and Hepatology,
Zhongshan Hospital of Fudan University, 180
Fenglin Road, Xuhui District,Shanghai, P. R. China
Cai Yu
Department of Gastroenterology and Hepatology,
Zhongshan Hospital of Fudan University, 180
Fenglin Road, Xuhui District,Shanghai, P. R. China
DOI
https://doi.org/10.1515/med-2020-0101
Journal volume & issue
Vol. 15,
no. 1
Abstract
Read online
S100A6 protein (calcyclin), a small calcium-binding protein of the S100 family, is often upregulated in various types of cancers, including hepatocellular carcinoma (HCC). The aim of this study was to illustrate the molecular mechanism of S100A6 in regulating the proliferation and migration of HCC cells.
Keywords
WeChat QR code
Close
