Coordination of H2O2 on praseodymia nanorods and its application in sensing cholesterol

Lei Jiang; Junjie Zhong; Youxun Li; Hanyun Liu; Shuyuan Zhang; Xiudong Zhu; Zhibin Liu; Yuxue Chen; Susana Fernandez-Garcia; Xiaowei Chen

Journal of Science: Advanced Materials and Devices (Jun 2022)

Coordination of H2O2 on praseodymia nanorods and its application in sensing cholesterol

Lei Jiang,
Junjie Zhong,
Youxun Li,
Hanyun Liu,
Shuyuan Zhang,
Xiudong Zhu,
Zhibin Liu,
Yuxue Chen,
Susana Fernandez-Garcia,
Xiaowei Chen

Affiliations

Lei Jiang: Center for Bioengineering and Biotechnology, College of Chemical Engineering, China University of Petroleum (East China), Qingdao 266580, China; Corresponding author.
Junjie Zhong: Center for Bioengineering and Biotechnology, College of Chemical Engineering, China University of Petroleum (East China), Qingdao 266580, China
Youxun Li: Marine Science Research Institute of Shandong Province & National Oceanographic Center, 7 Youyun Road, Qingdao 266104, China
Hanyun Liu: Department of Infectious Diseases, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, PR China
Shuyuan Zhang: Center for Bioengineering and Biotechnology, College of Chemical Engineering, China University of Petroleum (East China), Qingdao 266580, China
Xiudong Zhu: Center for Bioengineering and Biotechnology, College of Chemical Engineering, China University of Petroleum (East China), Qingdao 266580, China
Zhibin Liu: Center for Bioengineering and Biotechnology, College of Chemical Engineering, China University of Petroleum (East China), Qingdao 266580, China
Yuxue Chen: Center for Bioengineering and Biotechnology, College of Chemical Engineering, China University of Petroleum (East China), Qingdao 266580, China
Susana Fernandez-Garcia: Departamento de Ciencia de los Materiales, Ingeniería Metalúrgica y Química Inorgánica, Facultad de Ciencias and Instituto Universitario de Investigación en Microscopía Electrónica y Materiales (IMEYMAT), Universidad de Cádiz, Puerto Real, Cádiz E-11510, Spain
Xiaowei Chen: Departamento de Ciencia de los Materiales, Ingeniería Metalúrgica y Química Inorgánica, Facultad de Ciencias and Instituto Universitario de Investigación en Microscopía Electrónica y Materiales (IMEYMAT), Universidad de Cádiz, Puerto Real, Cádiz E-11510, Spain; Corresponding author.

Journal volume & issue: Vol. 7, no. 2
p. 100443

Abstract

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The advancement of functional nanomaterials has promoted the development of biomarker sensors underpinning promising analytical tools for a range of bioanalytes such as cholesterol. In this work, we established a light-on fluorescent probe for cholesterol in human serum by coordination of H2O2 on the surface of praseodymia nanorods (Pr6O11 NRs). The distinctive interactions of various nucleotides and H2O2 with praseodymia were examined, whereby good fluorescent quenching and recovery capability were observed. A highly sensitive and selective cholesterol detection was achieved in serum samples with a detection limit of 0.1 μM and recovery of 97.2–101.3%, respectively, due to the high oxygen mobility of praseodymia. The result suggests strong potential for work towards a key probe for a portable clinical test system for cholesterol as well as other H2O2-deriving biomarkers, potentially addressing the ever-increasing demand for the prevention of cardiovascular disease.

Published in Journal of Science: Advanced Materials and Devices

ISSN: 2468-2284 (Print); 2468-2179 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/journal-of-science-advanced-materials-and-devices

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