Drug Design, Development and Therapy (Jun 2020)

Sugar Codes Conjugated Alginate: An Innovative Platform to Make a Strategic Breakthrough in Simultaneous Prophylaxis of GERD and Helicobacter pylori Infection

  • Moayedi S,
  • Yadegar A,
  • Balalaie S,
  • Yarmohammadi M,
  • Zali MR,
  • Suzuki H,
  • Fricker G,
  • Haririan I

Journal volume & issue
Vol. Volume 14
pp. 2405 – 2412

Abstract

Read online

Saeed Moayedi,1 Abbas Yadegar,2 Saeed Balalaie,3 Mahdiyeh Yarmohammadi,2 Mohammad Reza Zali,4 Hidekazu Suzuki,5 Gert Fricker,6 Ismaeil Haririan1 1Department of Pharmaceutical Biomaterials, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; 2Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3Peptide Chemistry Research Center, K. N. Toosi University of Technology, Tehran, Iran; 4Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 5Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan; 6Institute of Pharmacy and Molecular Biotechnology, Ruprecht-Karls-University, Heidelberg, GermanyCorrespondence: Ismaeil HaririanDepartment of Pharmaceutical Biomaterials, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranEmail [email protected]: Currently, gastroesophageal reflux disease (GERD) is one of the most ubiquitous problems in clinical practice. An antacid-alginate combination (under the trade name Gaviscon) is a natural-based product that effectively suppresses GERD. This product acts via the formation of viscous gel that floats on the top of the gastric content. On the other hand, efficient management of Helicobacter pylori infection with minimal side effects is an important goal for gastroenterologists. Furthermore, some H. pylori-positive patients suffer from GERD.Methods: Here, we present the results of investigations on alginate conjugated to sugar codes in order to find initial clues regarding the potential ability of this conjugate in the simultaneous prophylaxis of GERD and H. pylori infection in an in vitro assay.Results: It is noteworthy that our results reveal that sugar codes conjugated alginate considerably decrease (approximately 74%) the adhesion of H. pylori to gastric epithelial cells in vitro. Moreover, surprisingly after conjugation of sugar codes, alginate can maintain its ability to create gel. Our results demonstrate that alginate conjugated to sugar codes is not cytotoxic.Conclusion: The preparation of these conjugates can be regarded as the first step to establish a new roadmap for the simultaneous prevention of GERD and H. pylori infection in future studies on in vivo models.Keywords: GERD, Helicobacter pylori infection, sugar codes, alginate, conjugation

Keywords