Oral Erythritol Reduces Energy Intake during a Subsequent <i>ad libitum</i> Test Meal: A Randomized, Controlled, Crossover Trial in Healthy Humans
Fabienne Teysseire,
Emilie Flad,
Valentine Bordier,
Aleksandra Budzinska,
Nathalie Weltens,
Jens F. Rehfeld,
Christoph Beglinger,
Lukas Van Oudenhove,
Bettina K. Wölnerhanssen,
Anne Christin Meyer-Gerspach
Affiliations
Fabienne Teysseire
St. Clara Research Ltd. at St. Claraspital, 4002 Basel, Switzerland
Emilie Flad
St. Clara Research Ltd. at St. Claraspital, 4002 Basel, Switzerland
Valentine Bordier
St. Clara Research Ltd. at St. Claraspital, 4002 Basel, Switzerland
Aleksandra Budzinska
Translational Research Center for Gastrointestinal Disorders, Laboratory for Brain-Gut Axis Studies, Department of Chronic Diseases and Metabolism, Catholic University of Leuven, 3000 Leuven, Belgium
Nathalie Weltens
Translational Research Center for Gastrointestinal Disorders, Laboratory for Brain-Gut Axis Studies, Department of Chronic Diseases and Metabolism, Catholic University of Leuven, 3000 Leuven, Belgium
Jens F. Rehfeld
Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, 1172 Copenhagen, Denmark
Christoph Beglinger
St. Clara Research Ltd. at St. Claraspital, 4002 Basel, Switzerland
Lukas Van Oudenhove
Translational Research Center for Gastrointestinal Disorders, Laboratory for Brain-Gut Axis Studies, Department of Chronic Diseases and Metabolism, Catholic University of Leuven, 3000 Leuven, Belgium
Bettina K. Wölnerhanssen
St. Clara Research Ltd. at St. Claraspital, 4002 Basel, Switzerland
Anne Christin Meyer-Gerspach
St. Clara Research Ltd. at St. Claraspital, 4002 Basel, Switzerland
The impact of oral erythritol on subsequent energy intake is unknown. The aim was to assess the effect of oral erythritol compared to sucrose, sucralose, or tap water on energy intake during a subsequent ad libitum test meal and to examine the release of cholecystokinin (CCK) in response to these substances. In this randomized, crossover trial, 20 healthy volunteers received 50 g erythritol, 33.5 g sucrose, or 0.0558 g sucralose dissolved in tap water, or tap water as an oral preload in four different sessions. Fifteen minutes later, a test meal was served and energy intake was assessed. At set time points, blood samples were collected to quantify CCK concentrations. The energy intake (ad libitum test meal) was significantly lower after erythritol compared to sucrose, sucralose, or tap water (p ad libitum test meal, erythritol led to a significant increase in CCK compared to sucrose, sucralose, or tap water (p ad libitum test meal and reduced subsequent energy intake compared to sucrose, sucralose, or tap water. These properties make erythritol a useful sugar alternative.