Features of hemodynamic parameters during chronic and acute episodic introduction of ethanol to animals in model experiments

Abstract

Diseases of the cardiovascular system continue to occupy the first place in the world among all causes of death in the population. One of the leading medical and social factors in the growth of the number of cardiovascular pathologies is alcohol consumption.The purpose of this work: to study the effect of chronic and acute episodic administration of ethanol on the features of hemodynamic parameters in rats.Materials and methods. The study was carried out on non-linear mature male rats. The group that underwent acute administration of ethanol every five days (days 1,6, 11, 16, 21) was intraperitoneally injected with a 20 % ethanol solution (5 g/kg).The group subjected to chronic alcoholization was offered 10 % ethanol solution as the only source of liquid for 21 days. Every five days in both groups, hemodynamic parameters such as systolic (SBP) and diastolic (DBP) blood pressure, heart rate (HR) were recorded.Results. With acute use of ethanol, already 30 minutes after administration, changes in hemodynamic parameters were found in the form of a decrease in SBP and DBP by an average of 43 %.60 minutes after the administration of ethanol, there was an increase in SBP and DBP by an average of 11 % relative to the initial data, which at the initial stage of alcohol consumption may be associated with a compensatory reaction of the cardiosystem in response to alcohol poisoning. Under conditions of chronic ethanol use, there was a decrease in the level of SBP, DBP and heart rate by an average of 16 % on the first day of the study, followed by their recovery to the initial values on the 21 st day of the study, which may be a sign of the development of a compensatory reaction of the body and indicate the beginning of the formation of alcoholic dependencies.Conclusions. Acute and chronic administration of ethanol has a significant, but at the same time multidirectional effect on hemodynamic parameters, which can serve as a trigger for the development of various cardiopathologies.

Keywords

• hemodynamics
• acute administration of ethanol
• chronic alcoholization
• heart rate
• blood pressure