Molecular aspects of the T-helpers type 17 functioning

Abstract

The article presents up-to-date data on the functioning of the T-helper type 17 (Th17). History of the Th17 discovery, transcription factors, mechanisms, mediating stimulation and inhibition of the Th17 differentiation, are described. Cytokines, which are produced by this lymphoid subset, and signaling pathways, through which its effects are realized, are listed. A brief description is given of the main physiological processes and diseases, in which participation of the Th17 was described.

Keywords

• т-хелперы 17-го типа
• цитокины
• иммунорегуляция