New Methodology for the Synthesis of Thiobarbiturates Mediated by Manganese(III) Acetate

Abstract

A three step synthesis of various thiobarbiturate derivatives 17–24 was established. The first step is mediated by Mn(OAc)3, in order to generate a carbon-carbon bond between a terminal alkene and malonate. Derivatives 1–8 were obtained in moderate to good yields under mild conditions. This key step allows synthesis of a wide variety of lipophilic thiobarbiturates, which could be tested for their anticonvulsive or anesthesic potential.

Keywords

• manganese(III) acetate
• barbiturates
• radical