GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation

Chikashi Terao; Yukihide Momozawa; Kazuyoshi Ishigaki; Eiryo Kawakami; Masato Akiyama; Po-Ru Loh; Giulio Genovese; Hiroki Sugishita; Tazro Ohta; Makoto Hirata; John R. B. Perry; Koichi Matsuda; Yoshinori Murakami; Michiaki Kubo; Yoichiro Kamatani

doi:10.1038/s41467-019-12705-5

Nature Communications (Oct 2019)

GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation

Chikashi Terao,
Yukihide Momozawa,
Kazuyoshi Ishigaki,
Eiryo Kawakami,
Masato Akiyama,
Po-Ru Loh,
Giulio Genovese,
Hiroki Sugishita,
Tazro Ohta,
Makoto Hirata,
John R. B. Perry,
Koichi Matsuda,
Yoshinori Murakami,
Michiaki Kubo,
Yoichiro Kamatani

Affiliations

Chikashi Terao: Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences
Yukihide Momozawa: Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences
Kazuyoshi Ishigaki: Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences
Eiryo Kawakami: Healthcare and Medical Data Driven AI based Predictive Reasoning Development Unit, Medical Sciences Innovation Hub Program (MIH), RIKEN
Masato Akiyama: Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences
Po-Ru Loh: Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
Giulio Genovese: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
Hiroki Sugishita: Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Science (IMS)
Tazro Ohta: Database Center for Life Science, Joint Support-Center for Data Science Research, Research Organization of Information and Systems
Makoto Hirata: Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of Tokyo
John R. B. Perry: MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge
Koichi Matsuda: Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of Tokyo
Yoshinori Murakami: Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo
Michiaki Kubo: Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences
Yoichiro Kamatani: Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences

DOI: https://doi.org/10.1038/s41467-019-12705-5
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 10

Abstract

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Mosaic loss of chromosome Y (mLOY) is associated with age and smoking but also genetic factors play a role. Here, Terao et al. perform GWAS for mLOY in 95,380 Japanese men and identify 46 loci that overlap with hematopoietic stem cell enhancers and transcription factor binding sites critical for hematopoiesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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