The Effect of Adding Magnesium Oxide Nanoparticles to The Cold Cured Acrylic Resin on Candida albicans Adhesion

Abstract

Aims: This study aims to assess the impact of the addition of MgO nanoparticles(NPs) with size of 50nm at different concentrations, which are 1.25%,2.5% and 5% on adherence of Candida albicans to cold- cured acrylic resin. Materials and Methods: Twenty-four specimens with the dimensions of (10mm ×10mm×2mm)length, width, and thickness respectively were made and divided into four groups, 6 specimens for each group; controlled (without the addition of MgO NPs) ,group of 1.25% MgO NPs ,group of 2.5% MgO NPs and group of 5% MgO NPs; were subjected to adherence test. The statistical analysis was done by using SPSS program including descriptive statistics, ANOVA, and the Duncan΄s test at p ≤ 0.05. Results: Results showed that, the maximum reduction in Candida albicans adherence obtained at a concentration of 5% followed by 2.5% then 1.25% ; while the control group showed that the highest number of Candida albicans colonies adhered to cold-cured acrylic. Conclusions: The MgO NPs influenced the adherence of Candida albicans to cold-cured acrylic resin, there is a significant reduction in the number of Candida albicans attached to cold-cured acrylic modified with MgO nanoparticles at different concentrations; and this reduction increases with increasing the concentration of MgO nanoparticles.