BMJ Open Respiratory Research (Jan 2021)
Symptomatic, biochemical and radiographic recovery in patients with COVID-19
- Onn Min Kon,
- Chloe I Bloom,
- Felicity Liew,
- Kartik Kumar,
- Clare Ross,
- laura Martin,
- Jian Chen,
- Jamilah Meghji,
- Dominic Hampson,
- Patrick Mallia,
- Brandon Wong,
- Victoria Pilkington,
- Shaan Chhabra,
- Ben Russell,
- Karthikan Srikanthan,
- Mirae Park,
- Harriet Owles,
- Joana Alcada,
- Meg Coleman,
- Sarah Elkin,
- Shweta Agrawal,
- Thomas Gardiner,
- Aaron Bell,
- Alice White,
- Gauri Vithlani,
- Kavina Manalan,
- Solange Bramer,
- Alejandra Martin Segura,
- Anushree Kucheria,
- Prashanthi Ratnakumar,
- Alexander Sheeka,
- Lavanya Anandan,
- Susan Copley,
- Georgina Russell
Affiliations
- Onn Min Kon
- 1 Department of Respiratory Medicine, St Mary`s Hospital, Imperial College Healthcare NHS Trust, London, UK
- Chloe I Bloom
- 1 Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College London, London, UK
- Felicity Liew
- Respiratory Medicine, Royal Brompton Hospital, London, UK
- Kartik Kumar
- 1 Department of Respiratory Medicine, St Mary`s Hospital, Imperial College Healthcare NHS Trust, London, UK
- Clare Ross
- Imperial College Healthcare NHS Trust, London, UK
- laura Martin
- 1 Department of Respiratory Medicine, St Mary`s Hospital, Imperial College Healthcare NHS Trust, London, UK
- Jian Chen
- Department of Digestive Diseases, Huashan Hospital Fudan University, Shanghai, China
- Jamilah Meghji
- Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK
- Dominic Hampson
- Imperial College Healthcare NHS Trust, London, UK
- Patrick Mallia
- National Heart and Lung Institute, Imperial College London, London, UK
- Brandon Wong
- Imperial College Healthcare NHS Trust, London, UK
- Victoria Pilkington
- Nuffield Department of Population Health, University of Oxford, Oxford, UK
- Shaan Chhabra
- Imperial College Healthcare NHS Trust, London, UK
- Ben Russell
- Imperial College Healthcare NHS Trust, London, UK
- Karthikan Srikanthan
- 1 National Heart and Lung Institute, Imperial College London, London, UK
- Mirae Park
- 1 Department of Respiratory Medicine, St Mary`s Hospital, Imperial College Healthcare NHS Trust, London, UK
- Harriet Owles
- Imperial College Healthcare NHS Trust, London, UK
- Joana Alcada
- Imperial College Healthcare NHS Trust, London, UK
- Meg Coleman
- 1 Department of Respiratory Medicine, St Mary`s Hospital, Imperial College Healthcare NHS Trust, London, UK
- Sarah Elkin
- 9 Respiratory Medicine, Imperial College Healthcare NHS Trust, London, UK
- Shweta Agrawal
- Imperial College Healthcare NHS Trust, London, UK
- Thomas Gardiner
- Imperial College Healthcare NHS Trust, London, UK
- Aaron Bell
- Imperial College Healthcare NHS Trust, London, UK
- Alice White
- Southampton University Hospitals Trust
- Gauri Vithlani
- Imperial College Healthcare NHS Trust, London, UK
- Kavina Manalan
- Imperial College Healthcare NHS Trust, London, UK
- Solange Bramer
- Faculty of Medicine, Imperial College London, London, UK
- Alejandra Martin Segura
- Imperial College School of Medicine, Imperial College, London, UK
- Anushree Kucheria
- Imperial College School of Medicine, Imperial College, London, UK
- Prashanthi Ratnakumar
- Imperial College Healthcare NHS Trust, London, UK
- Alexander Sheeka
- Imperial College Healthcare NHS Trust, London, UK
- Lavanya Anandan
- Imperial College Healthcare NHS Trust, London, UK
- Susan Copley
- Radiology Department, Imperial College Healthcare NHS Trust, London, UK
- Georgina Russell
- 1 Department of Respiratory Medicine, St Mary`s Hospital, Imperial College Healthcare NHS Trust, London, UK
- DOI
- https://doi.org/10.1136/bmjresp-2021-000908
- Journal volume & issue
-
Vol. 8,
no. 1
Abstract
Background The symptoms, radiography, biochemistry and healthcare utilisation of patients with COVID-19 following discharge from hospital have not been well described.Methods Retrospective analysis of 401 adult patients attending a clinic following an index hospital admission or emergency department attendance with COVID-19. Regression models were used to assess the association between characteristics and persistent abnormal chest radiographs or breathlessness.Results 75.1% of patients were symptomatic at a median of 53 days post discharge and 72 days after symptom onset and chest radiographs were abnormal in 47.4%. Symptoms and radiographic abnormalities were similar in PCR-positive and PCR-negative patients. Severity of COVID-19 was significantly associated with persistent radiographic abnormalities and breathlessness. 18.5% of patients had unscheduled healthcare visits in the 30 days post discharge.Conclusions Patients with COVID-19 experience persistent symptoms and abnormal blood biomarkers with a gradual resolution of radiological abnormalities over time. These findings can inform patients and clinicians about expected recovery times and plan services for follow-up of patients with COVID-19.
