Association of polymorphisms of HLA-DRB1 and TNF-308 G/A with radiographic joint damage in patients with early rheumatoid arthritis with high inflammatory activity, treated according to the principle of “Treat to target” (REMARKA study)

I A Guseva; A V Smirnov; N V Demidova; M Yu Krylov; A S Avdeeva; E Yu Samarkina; E L Luchikhina; D E Karateev; D D Abramov; E L Nasonov

doi:10.26442/terarkh201890538-43

Терапевтический архив (May 2018)

Association of polymorphisms of HLA-DRB1 and TNF-308 G/A with radiographic joint damage in patients with early rheumatoid arthritis with high inflammatory activity, treated according to the principle of “Treat to target” (REMARKA study)

I A Guseva,
A V Smirnov,
N V Demidova,
M Yu Krylov,
A S Avdeeva,
E Yu Samarkina,
E L Luchikhina,
D E Karateev,
D D Abramov,
E L Nasonov

Affiliations

I A Guseva: Federal State Budgetary Scientific Institution «Research Institute of Rheumatology named after V.A. Nasonova»
A V Smirnov: Federal State Budgetary Scientific Institution «Research Institute of Rheumatology named after V.A. Nasonova»
N V Demidova: Federal State Budgetary Scientific Institution «Research Institute of Rheumatology named after V.A. Nasonova»
M Yu Krylov: Federal State Budgetary Scientific Institution «Research Institute of Rheumatology named after V.A. Nasonova»
A S Avdeeva: Federal State Budgetary Scientific Institution «Research Institute of Rheumatology named after V.A. Nasonova»
E Yu Samarkina: Federal State Budgetary Scientific Institution «Research Institute of Rheumatology named after V.A. Nasonova»
E L Luchikhina: Moscow Regional Research and Clinical Institute (MONIKI)
D E Karateev: Moscow Regional Research and Clinical Institute (MONIKI)
D D Abramov: National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia
E L Nasonov: Federal State Budgetary Scientific Institution «Research Institute of Rheumatology named after V.A. Nasonova»; Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation

DOI: https://doi.org/10.26442/terarkh201890538-43
Journal volume & issue: Vol. 90, no. 5
pp. 38 – 43

Abstract

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Objective. To clarify the association between HLA-DRB1 and TNFα (-308G>A) genes polymorphism and joint destruction/further progression during 12 months of the follow-up period (FUP) in patients with early (

Published in Терапевтический архив

ISSN: 0040-3660 (Print); 2309-5342 (Online)
Publisher: "Consilium Medicum" Publishing house
Country of publisher: Russian Federation
LCC subjects: Medicine
Website: http://ter-arkhiv.ru/en/

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