Nature Communications (Oct 2022)
Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice
- Takayoshi Sasako,
- Toshihiro Umehara,
- Kotaro Soeda,
- Kazuma Kaneko,
- Miho Suzuki,
- Naoki Kobayashi,
- Yukiko Okazaki,
- Miwa Tamura-Nakano,
- Tomoki Chiba,
- Domenico Accili,
- C. Ronald Kahn,
- Tetsuo Noda,
- Hiroshi Asahara,
- Toshimasa Yamauchi,
- Takashi Kadowaki,
- Kohjiro Ueki
Affiliations
- Takayoshi Sasako
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- Toshihiro Umehara
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- Kotaro Soeda
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- Kazuma Kaneko
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- Miho Suzuki
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- Naoki Kobayashi
- Department of Molecular Diabetic Medicine, Diabetes Research Center, National Center for Global Health and Medicine
- Yukiko Okazaki
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- Miwa Tamura-Nakano
- Communal Laboratory, Research Institute, National Center for Global Health and Medicine
- Tomoki Chiba
- Department of Systems BioMedicine, Tokyo Medical and Dental University
- Domenico Accili
- Columbia University College of Physicians & Surgeons, Department of Medicine
- C. Ronald Kahn
- Joslin Diabetes Center, Harvard Medical School
- Tetsuo Noda
- Department of Cell Biology, Cancer Institute, Japanese Foundation of Cancer Research
- Hiroshi Asahara
- Department of Systems BioMedicine, Tokyo Medical and Dental University
- Toshimasa Yamauchi
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- Takashi Kadowaki
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- Kohjiro Ueki
- Department of Molecular Diabetic Medicine, Diabetes Research Center, National Center for Global Health and Medicine
- DOI
- https://doi.org/10.1038/s41467-022-33008-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Sasako et al. show that disruption of the insulin/IGF-1 signaling by suppressing Akt activity in mouse skeletal muscle can accelerate osteosarcopenia and shortens lifespan, which is reversed by inactivation of FoxOs rather than activation of mTOR, suggesting FoxOs as therapeutic targets.
