Biocompatible Alginate Hydrogel Film Containing Acetic Acid Manifests Broad-Spectrum Antiviral and Anticancer Activities
Alba Cano-Vicent,
Alberto Tuñón-Molina,
Hamid Bakshi,
Iman M. Alfagih,
Murtaza M. Tambuwala,
Ángel Serrano-Aroca
Affiliations
Alba Cano-Vicent
Biomaterials and Bioengineering Lab, Centro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia San Vicente Mártir, 46001 Valencia, Spain
Alberto Tuñón-Molina
Biomaterials and Bioengineering Lab, Centro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia San Vicente Mártir, 46001 Valencia, Spain
Hamid Bakshi
Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Iman M. Alfagih
Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 4545, Saudi Arabia
Murtaza M. Tambuwala
Brayford Pool Campus, Lincoln Medical School, University of Lincoln, Lincoln LN6 7TS, UK
Ángel Serrano-Aroca
Biomaterials and Bioengineering Lab, Centro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia San Vicente Mártir, 46001 Valencia, Spain
Acetic acid, a colourless liquid organic acid with a characteristic acrid smell, is obtained naturally and has applications in both the food and pharmaceutical industries. It has been reported to have beneficial uses for lifestyle-related diseases, and its efficient disinfectant properties are well known. In this study, an alginate crosslinked with Ca2+ hydrogel film was treated with acetic acid to explore its biological properties for biomedicine. The results showed that the novel calcium alginate/acetic acid film was biocompatible in vitro using human keratinocyte cells and in vivo with Caenorhabditis elegans. It also had antiviral properties against enveloped and non-enveloped viruses and anticancer properties against melanoma and colon cancer cells. This novel film thus showed promise for the biomedical and pharmaceutical industries, with applications for fabricating broad-spectrum antiviral and anticancer materials.
