Molecular Mechanism of Oxidative Stress Mediated Androgen Receptor Signal Reactivation in Prostatic Cancer Progression

Abstract

After androgen-deprivation therapy, a large amount of reactive oxygen species are produced in patients with advanced prostate cancer (PCa) to aggravate oxidative stress. This article explains the different molecular mechanisms by which oxidative stress regulates the androgenreceptor and its signaling pathways, such as oxidative stress mediated transcription factors induce AR expression, leading to increased local androgen levels in tumors; increased AR sensitivity leads to decreased level of testosterone and induce the bypass via AR activation, in order to explore the molecular mechanism of PCa evolution to castration-resistant prostate cancer, providing new ideas for the prevention, diagnosis and treatment of castration-resistant prostate cancer.

Keywords

• |prostatic neoplasms|reactive oxygen species|oxdative stress|receptors, androgen|prostate cancer|castration-resistant prostate cancer|signaling pathway|review