Nature Communications (Dec 2019)

An intravital window to image the colon in real time

  • Nikolai Rakhilin,
  • Aliesha Garrett,
  • Chi-Yong Eom,
  • Katherine Ramos Chavez,
  • David M. Small,
  • Andrea R. Daniel,
  • Melanie M. Kaelberer,
  • Menansili A. Mejooli,
  • Qiang Huang,
  • Shengli Ding,
  • David G. Kirsch,
  • Diego V. Bohórquez,
  • Nozomi Nishimura,
  • Bradley B. Barth,
  • Xiling Shen

DOI
https://doi.org/10.1038/s41467-019-13699-w
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 10

Abstract

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Performing intravital imaging of the colon in mouse models is challenging due to the colon’s anatomic location and motility. Here, the authors develop a murine colonic window for intravital chronic imaging that maximises long-term animal survival and minimises motion artefacts.