Nature Communications (Aug 2019)
AAV-ie enables safe and efficient gene transfer to inner ear cells
- Fangzhi Tan,
- Cenfeng Chu,
- Jieyu Qi,
- Wenyan Li,
- Dan You,
- Ke Li,
- Xin Chen,
- Weidong Zhao,
- Cheng Cheng,
- Xiaoyi Liu,
- Yunbo Qiao,
- Bing Su,
- Shuijin He,
- Chao Zhong,
- Huawei Li,
- Renjie Chai,
- Guisheng Zhong
Affiliations
- Fangzhi Tan
- iHuman Institute, ShanghaiTech University
- Cenfeng Chu
- iHuman Institute, ShanghaiTech University
- Jieyu Qi
- MOE Key Laboratory for Developmental Genes and Human Disease, Institute of Life Sciences, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University
- Wenyan Li
- ENT Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, Key Laboratory of Hearing Medicine of NHFPC, Shanghai Engineering Research Centre of Cochlear Implant, State Key Laboratory of Medical Neurobiology, Fudan University
- Dan You
- ENT Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, Key Laboratory of Hearing Medicine of NHFPC, Shanghai Engineering Research Centre of Cochlear Implant, State Key Laboratory of Medical Neurobiology, Fudan University
- Ke Li
- University of the Chinese Academy of Sciences
- Xin Chen
- School of Life Science and Technology, ShanghaiTech University
- Weidong Zhao
- ENT Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, Key Laboratory of Hearing Medicine of NHFPC, Shanghai Engineering Research Centre of Cochlear Implant, State Key Laboratory of Medical Neurobiology, Fudan University
- Cheng Cheng
- Department of Otolaryngology Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Provincial Key Medical Discipline (Laboratory)
- Xiaoyi Liu
- iHuman Institute, ShanghaiTech University
- Yunbo Qiao
- Precise Genome Engineering Center, School of Life Sciences, Guangzhou University
- Bing Su
- iHuman Institute, ShanghaiTech University
- Shuijin He
- School of Life Science and Technology, ShanghaiTech University
- Chao Zhong
- School of Physical Science and Technology, ShanghaiTech University
- Huawei Li
- ENT Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, Key Laboratory of Hearing Medicine of NHFPC, Shanghai Engineering Research Centre of Cochlear Implant, State Key Laboratory of Medical Neurobiology, Fudan University
- Renjie Chai
- MOE Key Laboratory for Developmental Genes and Human Disease, Institute of Life Sciences, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University
- Guisheng Zhong
- iHuman Institute, ShanghaiTech University
- DOI
- https://doi.org/10.1038/s41467-019-11687-8
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 10
Abstract
There are currently few AAV vectors that can effectively target the diverse cell types of the inner ear. Here the authors design AAV-ie for gene delivery to the mouse cochlea, targeting cochlear supporting cells.
