DAS181 Treatment of Severe Parainfluenza Virus 3 Pneumonia in Allogeneic Hematopoietic Stem Cell Transplant Recipients Requiring Mechanical Ventilation

B. Dhakal; A. D’Souza; M. Pasquini; W. Saber; T. S. Fenske; R. B. Moss; W. R. Drobyski; P. Hari; M. Z. Abidi

doi:10.1155/2016/8503275

Case Reports in Medicine (Jan 2016)

DAS181 Treatment of Severe Parainfluenza Virus 3 Pneumonia in Allogeneic Hematopoietic Stem Cell Transplant Recipients Requiring Mechanical Ventilation

B. Dhakal,
A. D’Souza,
M. Pasquini,
W. Saber,
T. S. Fenske,
R. B. Moss,
W. R. Drobyski,
P. Hari,
M. Z. Abidi

Affiliations

B. Dhakal: Division of Hematology Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
A. D’Souza: Division of Hematology Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
M. Pasquini: Division of Hematology Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
W. Saber: Division of Hematology Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
T. S. Fenske: Division of Hematology Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
R. B. Moss: Ansun BioPharma, San Diego, CA 92121, USA
W. R. Drobyski: Division of Hematology Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
P. Hari: Division of Hematology Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
M. Z. Abidi: Division of Infectious Disease, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA

DOI: https://doi.org/10.1155/2016/8503275
Journal volume & issue: Vol. 2016

Abstract

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Parainfluenza virus (PIV) may cause life-threatening pneumonia in allogeneic hematopoietic stem cell transplant (HSCT) recipients. Currently, there are no proven effective therapies. We report the use of inhaled DAS181, a novel sialidase fusion protein, for treatment of PIV type 3 pneumonia in two allogeneic hematopoietic SCT recipients with respiratory failure.

Published in Case Reports in Medicine

ISSN: 1687-9627 (Print); 1687-9635 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://onlinelibrary.wiley.com/journal/1683

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