Communications Biology (Mar 2021)
Advanced lipodystrophy reverses fatty liver in mice lacking adipocyte hormone-sensitive lipase
- Laura Pajed,
- Ulrike Taschler,
- Anna Tilp,
- Peter Hofer,
- Petra Kotzbeck,
- Stephanie Kolleritsch,
- Franz P. W. Radner,
- Isabella Pototschnig,
- Carina Wagner,
- Margarita Schratter,
- Sandra Eder,
- Sabrina Huetter,
- Renate Schreiber,
- Guenter Haemmerle,
- Thomas O. Eichmann,
- Martina Schweiger,
- Gerald Hoefler,
- Erin E. Kershaw,
- Achim Lass,
- Gabriele Schoiswohl
Affiliations
- Laura Pajed
- Institute of Molecular Biosciences, University of Graz
- Ulrike Taschler
- Institute of Molecular Biosciences, University of Graz
- Anna Tilp
- Institute of Molecular Biosciences, University of Graz
- Peter Hofer
- Institute of Molecular Biosciences, University of Graz
- Petra Kotzbeck
- Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz
- Stephanie Kolleritsch
- Institute of Molecular Biosciences, University of Graz
- Franz P. W. Radner
- Institute of Molecular Biosciences, University of Graz
- Isabella Pototschnig
- Institute of Molecular Biosciences, University of Graz
- Carina Wagner
- Institute of Molecular Biosciences, University of Graz
- Margarita Schratter
- Institute of Molecular Biosciences, University of Graz
- Sandra Eder
- Institute of Molecular Biosciences, University of Graz
- Sabrina Huetter
- Institute of Molecular Biosciences, University of Graz
- Renate Schreiber
- Institute of Molecular Biosciences, University of Graz
- Guenter Haemmerle
- Institute of Molecular Biosciences, University of Graz
- Thomas O. Eichmann
- Institute of Molecular Biosciences, University of Graz
- Martina Schweiger
- Institute of Molecular Biosciences, University of Graz
- Gerald Hoefler
- Diagnostic & Research Institute of Pathology, Medical University of Graz
- Erin E. Kershaw
- Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh
- Achim Lass
- Institute of Molecular Biosciences, University of Graz
- Gabriele Schoiswohl
- Institute of Molecular Biosciences, University of Graz
- DOI
- https://doi.org/10.1038/s42003-021-01858-z
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 13
Abstract
Pajed et al. investigate the role of adipocyte hormone-sensitive lipase (HSL) in whole body energy homeostasis. They show that adipocyte-specific HSL Knockout (AHKO) mice fed high fat diet develop fatty liver. Interestingly, this phenotype reverses in aged AHKO mice, possibly due to blunted lipolytic activity in adipose tissue with pronounced lipodystrophy.
