Dataset on cardiac structural and functional parameters in TMAO-challenged mouse
Yingyu Wang,
Chenchen Qin,
Shiyi Tian,
Yuqin Meng,
Yige Chen,
Sunjing Fu,
Mengting Xu,
Bing Wang,
Yuan Li,
Qin Ouyang,
Hao Ling,
Mingming Liu
Affiliations
Yingyu Wang
Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China; International Center of Microvascular Medicine, Chinese Academy of Medical Sciences, Beijing 100005, China
Chenchen Qin
School of Nursing, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100144, China
Shiyi Tian
School of Nursing, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100144, China
Yuqin Meng
School of Nursing, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100144, China
Yige Chen
School of Nursing, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100144, China
Sunjing Fu
Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China; International Center of Microvascular Medicine, Chinese Academy of Medical Sciences, Beijing 100005, China
Mengting Xu
Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China; International Center of Microvascular Medicine, Chinese Academy of Medical Sciences, Beijing 100005, China
Bing Wang
Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China; International Center of Microvascular Medicine, Chinese Academy of Medical Sciences, Beijing 100005, China
Yuan Li
Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China; International Center of Microvascular Medicine, Chinese Academy of Medical Sciences, Beijing 100005, China
Qin Ouyang
Department of Pathology, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China
Hao Ling
Department of Radiology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha 410000, Hunan, China
Mingming Liu
Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China; International Center of Microvascular Medicine, Chinese Academy of Medical Sciences, Beijing 100005, China; Diabetes Research Center, Chinese Academy of Medical Sciences, Beijing 100005, China; Corresponding author.
Trimethylamine-N-oxide (TMAO) is a gut-derived metabolite formed from dietary choline and l-carnitine, known to impede cholesterol metabolism and is implicated in the pathogenesis of thrombosis and atherosclerosis, contributing to the etiology of cardiovascular diseases. We present a dataset derived from an experimental study designed to elucidate the cardiotoxic effects of TMAO. This dataset encompasses echocardiographic assessments from two cohorts of mice: one subjected to a 6-week regimen of 20 mg/kg/day TMAO injections (n = 16) and a control group (n = 18). Each subject's echocardiographic dataset comprises six high-resolution TIFF images, capturing both B-type and M-mode views in standard echocardiographic planes, along with two additional M-mode images enriched with analysed cardiac functional data. Complementing these images, a CSV-formatted report details critical cardiac parameters, including heart rate, ejection fraction, and fractional shortening, among others. In a novel approach to enhance data integrity and permit tailored analyses, we provide the original output files from the echocardiography apparatus, which researchers can reprocess using dedicated analysis software. This dataset is anticipated to be instrumental in advancing our understanding of the mechanistic links between TMAO exposure and cardiac dysfunction.
