Antiparasitic Activities of Compounds Isolated from <i>Aspergillus fumigatus</i> Strain Discovered in Northcentral Nigeria
Oluwatofunmilayo A. Diyaolu,
Gagan Preet,
Adeshola A. Fagbemi,
Frederick Annang,
Guiomar Pérez-Moreno,
Cristina Bosch-Navarrete,
Olusoji O. Adebisi,
Emmanuel T. Oluwabusola,
Bruce F. Milne,
Marcel Jaspars,
Rainer Ebel
Affiliations
Oluwatofunmilayo A. Diyaolu
Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Aberdeen AB24 3UE, UK
Gagan Preet
Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Aberdeen AB24 3UE, UK
Adeshola A. Fagbemi
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Lead City University, Ibadan 200005, Nigeria
Frederick Annang
Fundación MEDINA, Parque Tecnológico de Ciencias de la Salud, Avenida del Conocimiento 34, Armilla, 18016 Granada, Spain
Guiomar Pérez-Moreno
Institut de Parasitiologia Biomedicina “Lopez-Neyra”, Consejo Superior de Investigaciones Cientificas (CSIC) Avda. Del Conocimiento 17, Armilla, 18016 Granada, Spain
Cristina Bosch-Navarrete
Institut de Parasitiologia Biomedicina “Lopez-Neyra”, Consejo Superior de Investigaciones Cientificas (CSIC) Avda. Del Conocimiento 17, Armilla, 18016 Granada, Spain
Olusoji O. Adebisi
School of Biosciences, Aston University Birmingham, Birmingham B4 7ET, UK
Emmanuel T. Oluwabusola
Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Aberdeen AB24 3UE, UK
Bruce F. Milne
Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Aberdeen AB24 3UE, UK
Marcel Jaspars
Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Aberdeen AB24 3UE, UK
Rainer Ebel
Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Aberdeen AB24 3UE, UK
In this study, we explored a fungal strain UIAU-3F identified as Aspergillus fumigatus isolated from soil samples collected from the River Oyun in Kwara State, Nigeria. In order to explore its chemical diversity, the fungal strain UIAU-3F was cultured in three different fermentation media, which resulted in different chemical profiles, evidenced by LC-ESI-MS-based metabolomics and multivariate analysis. The methanolic extract afforded two known compounds, fumitremorgin C (1) and pseurotin D (2). The in vitro antiparasitic assays of 1 against Trypanosoma cruzi and Plasmodium falciparum showed moderate activity with IC50 values of 9.6 µM and 2.3 µM, respectively, while 2 displayed IC50 values > 50 µM. Molecular docking analysis was performed on major protein targets to better understand the potential mechanism of the antitrypanosomal and antiplasmodial activities of the two known compounds.
