Nature Communications (Sep 2022)
DNA methylation signatures of Alzheimer’s disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types
- Gemma Shireby,
- Emma L. Dempster,
- Stefania Policicchio,
- Rebecca G. Smith,
- Ehsan Pishva,
- Barry Chioza,
- Jonathan P. Davies,
- Joe Burrage,
- Katie Lunnon,
- Dorothea Seiler Vellame,
- Seth Love,
- Alan Thomas,
- Keeley Brookes,
- Kevin Morgan,
- Paul Francis,
- Eilis Hannon,
- Jonathan Mill
Affiliations
- Gemma Shireby
- Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter Medical School, University of Exeter
- Emma L. Dempster
- Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter Medical School, University of Exeter
- Stefania Policicchio
- Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter Medical School, University of Exeter
- Rebecca G. Smith
- Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter Medical School, University of Exeter
- Ehsan Pishva
- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Maastricht University
- Barry Chioza
- Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter Medical School, University of Exeter
- Jonathan P. Davies
- Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter Medical School, University of Exeter
- Joe Burrage
- Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter Medical School, University of Exeter
- Katie Lunnon
- Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter Medical School, University of Exeter
- Dorothea Seiler Vellame
- Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter Medical School, University of Exeter
- Seth Love
- Dementia Research Group, University of Bristol Medical School (Translational Health Sciences)
- Alan Thomas
- Translational and Clinical Research Institute, Newcastle University
- Keeley Brookes
- Biosciences, School of Science & Technology, Nottingham Trent University
- Kevin Morgan
- Human Genetics, School of Life Sciences, University of Nottingham
- Paul Francis
- Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter Medical School, University of Exeter
- Eilis Hannon
- Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter Medical School, University of Exeter
- Jonathan Mill
- Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter Medical School, University of Exeter
- DOI
- https://doi.org/10.1038/s41467-022-33394-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Here the authors identify differences in cortical DNA methylation associated with Alzheimer’s disease pathology, and profiling nuclei from specific cell-types, find that most of these differences reflect variation occurring in non-neuronal cells.
