Microencapsulation and nanowarming enables vitrification cryopreservation of mouse preantral follicles

Conghui Tian; Lingxiao Shen; Chenjia Gong; Yunxia Cao; Qinghua Shi; Gang Zhao

doi:10.1038/s41467-022-34549-2

Nature Communications (Dec 2022)

Microencapsulation and nanowarming enables vitrification cryopreservation of mouse preantral follicles

Conghui Tian,
Lingxiao Shen,
Chenjia Gong,
Yunxia Cao,
Qinghua Shi,
Gang Zhao

Affiliations

Conghui Tian: Department of Electronic Engineering and Information Science, University of Science and Technology of China
Lingxiao Shen: Department of Electronic Engineering and Information Science, University of Science and Technology of China
Chenjia Gong: Division of Reproduction and Genetics, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Science at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, Biomedical Sciences and Health Laboratory of Anhui Province, CAS center for Excellence in Molecular Cell Science, Collaborative Innovation Center of Genetics and Development, University of Science and Technology of China
Yunxia Cao: Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University
Qinghua Shi: Division of Reproduction and Genetics, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Science at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, Biomedical Sciences and Health Laboratory of Anhui Province, CAS center for Excellence in Molecular Cell Science, Collaborative Innovation Center of Genetics and Development, University of Science and Technology of China
Gang Zhao: Department of Electronic Engineering and Information Science, University of Science and Technology of China

DOI: https://doi.org/10.1038/s41467-022-34549-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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Vitrification of preantral follicles is a promising strategy for female fertility preservation, but requires high concentrations of toxic cryoprotectants. Here, the authors accomplish follicle vitrification with low cryoprotectants by taking advantage of microencapsulation and nanowarming.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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