Nature Communications (Feb 2022)
Spatiotemporal dynamics of clonal selection and diversification in normal endometrial epithelium
- Manako Yamaguchi,
- Hirofumi Nakaoka,
- Kazuaki Suda,
- Kosuke Yoshihara,
- Tatsuya Ishiguro,
- Nozomi Yachida,
- Kyota Saito,
- Haruka Ueda,
- Kentaro Sugino,
- Yutaro Mori,
- Kaoru Yamawaki,
- Ryo Tamura,
- Sundaramoorthy Revathidevi,
- Teiichi Motoyama,
- Kazuki Tainaka,
- Roel G. W. Verhaak,
- Ituro Inoue,
- Takayuki Enomoto
Affiliations
- Manako Yamaguchi
- Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences
- Hirofumi Nakaoka
- Human Genetics Laboratory, National Institute of Genetics
- Kazuaki Suda
- Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences
- Kosuke Yoshihara
- Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences
- Tatsuya Ishiguro
- Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences
- Nozomi Yachida
- Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences
- Kyota Saito
- Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences
- Haruka Ueda
- Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences
- Kentaro Sugino
- Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences
- Yutaro Mori
- Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences
- Kaoru Yamawaki
- Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences
- Ryo Tamura
- Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences
- Sundaramoorthy Revathidevi
- Human Genetics Laboratory, National Institute of Genetics
- Teiichi Motoyama
- Department of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences
- Kazuki Tainaka
- Department of System Pathology for Neurological Disorders, Brain Research Institute, Niigata University
- Roel G. W. Verhaak
- The Jackson Laboratory for Genomic Medicine
- Ituro Inoue
- Human Genetics Laboratory, National Institute of Genetics
- Takayuki Enomoto
- Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences
- DOI
- https://doi.org/10.1038/s41467-022-28568-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Through regeneration, the endometrium accumulates somatic mutations that can lead to diseases like endometriosis and cancer. Here, the authors use genomics to analyse normal endometrial glands from different patient cohorts, detect rhizome structures with common clonal ancestors and infer clonal expansion dynamics.
