Patient Preference and Adherence (Dec 2021)
Preliminary Study on Reference Interval of Serum Pepsinogen in Healthy Subjects
Abstract
Liang Zhang, Ye Niu, Yin-Jiang Lv, Li-Feng Wu, Qi-Lei Hu, Rong Huang, Ru-Jin Xu Department of Clinical Laboratory, First People’s Hospital of Linping District, Hangzhou, Zhejiang, 311100, People’s Republic of ChinaCorrespondence: Ru-Jin XuDepartment of Clinical Laboratory, First People’s Hospital of Linping District, No. 369 Yingbin Road of Nanyuan Street, Linping District, Hangzhou, Zhejiang, 311100, People’s Republic of ChinaTel +86 571 89369407Email [email protected]: This study determined the reference interval of pepsinogen (PG) of healthy people in the local region to provide a basis for early screening of gastric cancer.Methods: Among the healthy people who underwent a physical examination in our hospital from January 2020 to December 2020, 2568 subjects were selected based on the relevant screening criteria. Their serum PG I and II levels and PG I:PG II ratio were determined by chemiluminescent microparticle immunoassay (CIMA), and the results were statistically analyzed. Finally, according to document CLSI-C28-A3, the PG reference interval of the local region was determined.Results: The PG I and II levels of the males in all age groups were higher than those of the females in the corresponding age groups, and the differences were statistically significant (P 0.05). The PG I and II levels increased with age in both men and women, while the PG I:PG II ratio was not correlated with age in either gender.Conclusion: The PG reference interval of the local region was initially determined as providing a reliable reference basis for clinical treatment.Keywords: pepsinogen, reference interval, chemiluminescent microparticle immunoassay, CLSI-C28-A3
