The Corellation Between Serum Ferritin and Cardiac Troponin I in Major Beta Thalassemia Children

Abstract

Major beta thalassemia (MBT) is a hereditary disease which synthesies defects in beta chains of haemoglobin, it is causes red blood cell destruction and the symptoms of anemia. Red blood cell destruction, frequent blood transfusion and low adherence to routine use of iron chelator lead to iron accumulation in the heart, liver and endocrine organs. Accumulation of iron in the myocard can lead acute myocardial infarction. One of cardiac markers that had been used for the diagnosis of myocardial infarction was cardiac troponin I (cTnI). The aim of this research is find the correlation between serum ferritin levels and cTnI in MBT children. A descriptive analytic research was conducted using a cross sectional design. The subjects were divided into 2 groups, the MBT group and the control group. In both groups, the serum ferritin and cTnI levels ere evaluated. Data were analyzed using t-test and Pearson correlation test. Eleven children in the MBT group and 11 children in the control group were involved in this study. In the MBT group, the mean of serum ferritin and cTnI levels were 4292.5 µg/L and 0.20 ng/mL respectively. The mean of serum ferritin levels in the MBT group were higher than in the control and statistically significant (p= 0.0004). The mean of serum ferritin levels in the MBT group were higher than in the control and statistically significant (p= 0.0004). The mean of serum cTnI in the MBT group were higher than in the control, but statistically not significant (p= 0.82). In the MBT group, there was a weak corellation between serum ferritin and cTnI levels (r= 0.34).

Keywords

• children
• cTnI
• ferritin
• Major beta thalassemia