Engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis

Aaron H. Morris; Kevin R. Hughes; Robert S. Oakes; Michelle M. Cai; Stephen D. Miller; David N. Irani; Lonnie D. Shea

doi:10.1038/s41467-020-17629-z

Nature Communications (Aug 2020)

Engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis

Aaron H. Morris,
Kevin R. Hughes,
Robert S. Oakes,
Michelle M. Cai,
Stephen D. Miller,
David N. Irani,
Lonnie D. Shea

Affiliations

Aaron H. Morris: Department of Biomedical Engineering, University of Michigan
Kevin R. Hughes: Department of Biomedical Engineering, University of Michigan
Robert S. Oakes: Department of Biomedical Engineering, University of Michigan
Michelle M. Cai: Department of Biomedical Engineering, University of Michigan
Stephen D. Miller: Department of Microbiology–Immunology and Interdepartmental Immunobiology Center, Northwestern University Feinberg School of Medicine
David N. Irani: Department of Neurology, University of Michigan Medical School
Lonnie D. Shea: Department of Biomedical Engineering, University of Michigan

DOI: https://doi.org/10.1038/s41467-020-17629-z
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 9

Abstract

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Monitoring changes in immune phenotype during the progression of multiple sclerosis can provide insight into disease progression and inform treatment. Here the authors develop engineered biomaterial-based immunological niches for easy access to innate immune cells in a mouse model of multiple sclerosis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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