An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway

Fuhui Meng; Yang Xiao; Yujia Ji; Ziyi Sun; Xiaoming Zhou

doi:10.1038/s41467-022-28946-w

Nature Communications (Mar 2022)

An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway

Fuhui Meng,
Yang Xiao,
Yujia Ji,
Ziyi Sun,
Xiaoming Zhou

Affiliations

Fuhui Meng: Department of Integrated Traditional Chinese and Western Medicine, Rare Diseases Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University
Yang Xiao: Department of Integrated Traditional Chinese and Western Medicine, Rare Diseases Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University
Yujia Ji: Department of Integrated Traditional Chinese and Western Medicine, Rare Diseases Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University
Ziyi Sun: Department of Integrated Traditional Chinese and Western Medicine, Rare Diseases Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University
Xiaoming Zhou: Department of Integrated Traditional Chinese and Western Medicine, Rare Diseases Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University

DOI: https://doi.org/10.1038/s41467-022-28946-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

Read online

The nonopioid sigma-1 receptor (σ1R) is localized to the endoplasmic reticulum (ER), interacts with multiple effector proteins and various synthetic ligands, and is implicated in many diseases. Here, authors provide structural and functional evidence to reveal the likely ligand entry pathway for σ1R.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal