Generation of an induced pluripotent stem cell line (KNIHi001-A) by reprogramming peripheral blood mononuclear cells isolated from a patient with Parkinson's disease

Daye Baek; Kun-Gu Lee; Hee-Young Sohn; Jung Hyun Park; Hye-Kyung Lee; Govigerel Bayarsaikhan; Sang-Won Yoo; Bonghee Lee; Joong-Seok Kim; Young Ho Koh; Munjin Kwon

Stem Cell Research (Apr 2024)

Generation of an induced pluripotent stem cell line (KNIHi001-A) by reprogramming peripheral blood mononuclear cells isolated from a patient with Parkinson's disease

Daye Baek,
Kun-Gu Lee,
Hee-Young Sohn,
Jung Hyun Park,
Hye-Kyung Lee,
Govigerel Bayarsaikhan,
Sang-Won Yoo,
Bonghee Lee,
Joong-Seok Kim,
Young Ho Koh,
Munjin Kwon

Affiliations

Daye Baek: Department of Chronic Disease Convergence Research, Division of Brain Disease Research, Korea National Institute of Health, Cheongju-si, Republic of Korea
Kun-Gu Lee: nSAGE Inc., Incheon, Republic of Korea
Hee-Young Sohn: Department of Chronic Disease Convergence Research, Division of Brain Disease Research, Korea National Institute of Health, Cheongju-si, Republic of Korea; Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
Jung Hyun Park: Department of Chronic Disease Convergence Research, Division of Brain Disease Research, Korea National Institute of Health, Cheongju-si, Republic of Korea
Hye-Kyung Lee: Department of Chronic Disease Convergence Research, Division of Brain Disease Research, Korea National Institute of Health, Cheongju-si, Republic of Korea
Govigerel Bayarsaikhan: Department of Anatomy and Cell Biology, Gachon University Graduate School of Medicine, Center for Regenerative Medicine, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Republic of Korea
Sang-Won Yoo: Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
Bonghee Lee: nSAGE Inc., Incheon, Republic of Korea; Department of Anatomy and Cell Biology, Gachon University Graduate School of Medicine, Center for Regenerative Medicine, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Republic of Korea
Joong-Seok Kim: Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
Young Ho Koh: Department of Chronic Disease Convergence Research, Division of Brain Disease Research, Korea National Institute of Health, Cheongju-si, Republic of Korea
Munjin Kwon: Department of Chronic Disease Convergence Research, Division of Brain Disease Research, Korea National Institute of Health, Cheongju-si, Republic of Korea; Corresponding author.

Journal volume & issue: Vol. 76
p. 103358

Abstract

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Parkinson's disease is a degenerative brain disorder characterized by dopamine neuronal degeneration and dopamine transporter loss. In this study, we generated an induced pluripotent stem cell (iPSC) line, KNIHi001-A, from the peripheral blood mononuclear cells (PBMCs) of a 76-year-old man with Parkinson's disease. The non-integrating Sendai virus was used to reprogram iPSCs. iPSCs exhibit pluripotent markers, a normal karyotype, viral clearance, and the ability to differentiate into the three germ layers.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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