Clinicopathological Features of Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma: A Case Report and Review of the Literature

Hiromasa Takakura; Takeru Hamashima; Hirohiko Tachino; Akira Nakazato; Hiroshi Minato; Masakiyo Sasahara; Hideo Shojaku

doi:10.3389/fsurg.2020.596796

Frontiers in Surgery (Nov 2020)

Clinicopathological Features of Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma: A Case Report and Review of the Literature

Hiromasa Takakura,
Takeru Hamashima,
Hirohiko Tachino,
Akira Nakazato,
Hiroshi Minato,
Masakiyo Sasahara,
Hideo Shojaku

Affiliations

Hiromasa Takakura: Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan
Takeru Hamashima: Department of Pathology, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan
Hirohiko Tachino: Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan
Akira Nakazato: Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan
Hiroshi Minato: Department of Diagnostic Pathology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan
Masakiyo Sasahara: Department of Pathology, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan
Hideo Shojaku: Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan

DOI: https://doi.org/10.3389/fsurg.2020.596796
Journal volume & issue: Vol. 7

Abstract

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Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is an extremely rare neoplasm of the nasopharynx. Accordingly, its clinical and pathological characteristics are not well-known. We report a case of TL-LGNPPA and review the relevant literature on TL-LGNPPA. A 38-year-old Japanese woman presented with a history of nasal obstruction that had persisted for 1 month after symptoms of a common cold (e.g., low-grade fever, sore throat, and fatigue). A pedunculated tumor of ~20 mm in diameter was found on the posterior edge of the nasal septum. The tumor was endoscopically resected. Based on careful histopathological and immunohistochemical examinations, it was diagnosed as TL-LGNPPA. At 5 years after surgery, the patient remained disease-free. TL-LGNPPA has a very good prognosis, and complete resection with a sufficient safety margin is recommended as the first-line treatment. The morphological characteristics and immunohistochemical findings, especially TTF-1 positivity and thyroglobulin negativity, are important for the diagnosis.

Published in Frontiers in Surgery

ISSN: 2296-875X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Surgery
Website: https://www.frontiersin.org/journals/surgery

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