Nature Communications (Aug 2022)
Tackling recalcitrant Pseudomonas aeruginosa infections in critical illness via anti-virulence monotherapy
- Vijay K. Singh,
- Marianna Almpani,
- Damien Maura,
- Tomoe Kitao,
- Livia Ferrari,
- Stefano Fontana,
- Gabriella Bergamini,
- Elisa Calcaterra,
- Chiara Pignaffo,
- Michele Negri,
- Thays de Oliveira Pereira,
- Frances Skinner,
- Manos Gkikas,
- Danielle Andreotti,
- Antonio Felici,
- Eric Déziel,
- Francois Lépine,
- Laurence G. Rahme
Affiliations
- Vijay K. Singh
- Department of Surgery, Harvard Medical School and Massachusetts General Hospital
- Marianna Almpani
- Department of Surgery, Harvard Medical School and Massachusetts General Hospital
- Damien Maura
- Department of Surgery, Harvard Medical School and Massachusetts General Hospital
- Tomoe Kitao
- Department of Surgery, Harvard Medical School and Massachusetts General Hospital
- Livia Ferrari
- Translational Biology Department, Aptuit (Verona) S.rl, an Evotec Company
- Stefano Fontana
- DMPK Department, Aptuit (Verona) S.rl, an Evotec Company
- Gabriella Bergamini
- Translational Biology Department, Aptuit (Verona) S.rl, an Evotec Company
- Elisa Calcaterra
- Translational Biology Department, Aptuit (Verona) S.rl, an Evotec Company
- Chiara Pignaffo
- DMPK Department, Aptuit (Verona) S.rl, an Evotec Company
- Michele Negri
- In vitro Chemotherapy Laboratory, Aptuit (Verona) S.r.l., an Evotec Company
- Thays de Oliveira Pereira
- Centre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique (INRS), Laval
- Frances Skinner
- Department of Chemistry, University of Massachusetts Lowell
- Manos Gkikas
- Department of Chemistry, University of Massachusetts Lowell
- Danielle Andreotti
- Global Synthetic Chemistry Department, Aptuit (Verona) S.r.l., an Evotec Company
- Antonio Felici
- Department of Microbiology Discovery, In Vitro Biology, Aptuit (Verona) S.r.l., an Evotec Company
- Eric Déziel
- Centre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique (INRS), Laval
- Francois Lépine
- Centre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique (INRS), Laval
- Laurence G. Rahme
- Department of Surgery, Harvard Medical School and Massachusetts General Hospital
- DOI
- https://doi.org/10.1038/s41467-022-32833-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Pseudomonas aeruginosa infections are increasingly difficult to treat due to the development of antimicrobial resistance. Here, the authors describe the synthesis, characterisation and efficacy of a quorum sensing inhibitor.
