Maternal glucose levels and late pregnancy circulating extracellular vesicle and particle miRNAs in the MADRES pregnancy cohort
Elizabeth C. Anderson,
Helen B. Foley,
Joshua J. Levy,
Megan E. Romano,
Jiang Gui,
Jessica L. Bentz,
Luis E. Maldonado,
Shohreh F. Farzan,
Theresa M. Bastain,
Carmen J. Marsit,
Carrie V. Breton,
Caitlin G. Howe
Affiliations
Elizabeth C. Anderson
Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA
Helen B. Foley
Division of Environmental Health, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Joshua J. Levy
Emerging Diagnostic and Investigative Technologies, Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
Megan E. Romano
Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA
Jiang Gui
Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, NH, USA
Jessica L. Bentz
Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA
Luis E. Maldonado
Division of Environmental Health, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Shohreh F. Farzan
Division of Environmental Health, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Theresa M. Bastain
Division of Environmental Health, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Carmen J. Marsit
Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA
Carrie V. Breton
Division of Environmental Health, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Caitlin G. Howe
Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA
Maternal hyperglycemia during pregnancy adversely affects maternal and child outcomes. While mechanisms are not fully understood, maternal circulating miRNAs may play a role. We examined whether continuous glucose levels and hyperglycemia subtypes (gestational diabetes, type 2 diabetes, and glucose intolerance) were associated with circulating miRNAs during late pregnancy. Seven miRNAs (hsa-miR-107, hsa-let-7b-5p, hsa-miR-126-3p, hsa-miR-181a-5p, hsa-miR-374a-5p, hsa-miR-382-5p, and hsa-miR-337-5p) were associated (p < 0.05) with either hyperglycemia or continuous glucose levels prior to multiple testing correction. These miRNAs target genes involved in pathways relevant to maternal and child health, including insulin signaling, placental development, energy balance, and appetite regulation.
