Veterinary Medicine: Research and Reports (Feb 2024)
Canine Atopic Dermatitis: Prevalence, Impact, and Management Strategies
Abstract
Yvonne Drechsler,1 Charli Dong,2 David E Clark,1 Gagandeep Kaur1 1College of Veterinary Medicine, Western University of Health Sciences, Pomona, CA, USA; 2Animal Dermatology Clinic, Pasadena, CA, USACorrespondence: Yvonne Drechsler, College of Veterinary Medicine, Western University of Health Sciences, 309 E. Second Street, Pomona, CA, 91711, USA, Tel +1 909 706 3535, Email [email protected]: Atopic dermatitis (AD) is a common inflammatory and pruritic allergic skin disease in humans and dogs worldwide. The pathogenesis of AD is multifactorial, immunologically complex, and may involve genetic factors, epidermal barrier dysfunction, microbiome changes, immune dysregulation, and allergic sensitization. Across species, prevalence of AD is on the rise. At present, there is no cure for canine AD (CAD). The treatment for CAD is multifaceted and aimed at controlling the pruritus, associated inflammation, and infections, repairing the skin barrier function, and dietary management. This review presents data on prevalence, impact, and complex immunological interactions in AD with a focus on subsequent management of the disease in the canine population. A multimodal approach for management of CAD to address varying clinical signs and responses to therapies is discussed.Keywords: immunopathology, topical therapies, systemic therapies, pruritus, immune therapies, alarmins
