KIM-1 and GADDI-153 gene expression in paracetamol-induced acute kidney injury: effects of N-acetylcysteine, N-acetylmethionine, and N-acetylglucosamine

Mohamed Nahed A.; Hassan Mohammed H.; Saleem Tahia H.; Mohamed Sotohy A.; El-Zeftawy Marwa; Ahmed Eman A.; Mostafa Nashwa A. M.; Hetta Helal F.; Hasan Al Shaimaa; Abdallah Ahmed Alamir Mahmoud

doi:10.1515/tjb-2021-0233

Türk Biyokimya Dergisi (Dec 2021)

KIM-1 and GADDI-153 gene expression in paracetamol-induced acute kidney injury: effects of N-acetylcysteine, N-acetylmethionine, and N-acetylglucosamine

Mohamed Nahed A.,
Hassan Mohammed H.,
Saleem Tahia H.,
Mohamed Sotohy A.,
El-Zeftawy Marwa,
Ahmed Eman A.,
Mostafa Nashwa A. M.,
Hetta Helal F.,
Hasan Al Shaimaa,
Abdallah Ahmed Alamir Mahmoud

Affiliations

Mohamed Nahed A.: Department of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt
Hassan Mohammed H.: Department of Medical Biochemistry, Faculty of Medicine, South Valley University, 83523 Qena, Egypt
Saleem Tahia H.: Department of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt
Mohamed Sotohy A.: Animal and Environmental Hygiene, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt
El-Zeftawy Marwa: Biochemistry Department, Faculty of Veterinary Medicine, New Valley University, New Valley, Egypt
Ahmed Eman A.: Biochemistry Department, Faculty of Veterinary Medicine, New Valley University, New Valley, Egypt
Mostafa Nashwa A. M.: Department of Histology, Faculty of Medicine, Assiut University, Assiut, Egypt
Hetta Helal F.: Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt
Hasan Al Shaimaa: Department of Medical Pharmacology, Faculty of Medicine, South Valley University, Qena, Egypt
Abdallah Ahmed Alamir Mahmoud: Department of Medical Biochemistry, Faculty of Medicine, Sohag University, Sohag, Egypt

DOI: https://doi.org/10.1515/tjb-2021-0233
Journal volume & issue: Vol. 47, no. 4
pp. 409 – 416

Abstract

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Acute kidney injury (AKI) is a critical clinical event characterized by a reduction in the excretory function of the kidneys. N-acetylcysteine (NAC), N-acetylmethionine (NAM) and N-acetylglucosamine (NAG) are antioxidants with scanty known genetic mechanisms. We aimed to assess both kidney injury molecule-1 (KIM-1) and growth-arrested DNA damage-inducible gene-153 (GADD-153) genes expression in paracetamol (PA) induced AKI. Also, to recognize whether NAC, NAM and/or NAG have roles in altering the expression of these genes for ameliorating the AKI induced by PA.

Published in Türk Biyokimya Dergisi

ISSN: 1303-829X (Online)
Publisher: De Gruyter
Country of publisher: Germany
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.degruyter.com/journal/key/tjb/html

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