Nature Communications (Nov 2018)
Epigenetic profiling for the molecular classification of metastatic brain tumors
- Javier I. J. Orozco,
- Theo A. Knijnenburg,
- Ayla O. Manughian-Peter,
- Matthew P. Salomon,
- Garni Barkhoudarian,
- John R. Jalas,
- James S. Wilmott,
- Parvinder Hothi,
- Xiaowen Wang,
- Yuki Takasumi,
- Michael E. Buckland,
- John F. Thompson,
- Georgina V. Long,
- Charles S. Cobbs,
- Ilya Shmulevich,
- Daniel F. Kelly,
- Richard A. Scolyer,
- Dave S. B. Hoon,
- Diego M. Marzese
Affiliations
- Javier I. J. Orozco
- Department of Translational Molecular Medicine, John Wayne Cancer Institute at Providence Saint John’s Health Center
- Theo A. Knijnenburg
- Institute for Systems Biology
- Ayla O. Manughian-Peter
- Department of Translational Molecular Medicine, John Wayne Cancer Institute at Providence Saint John’s Health Center
- Matthew P. Salomon
- Department of Translational Molecular Medicine, John Wayne Cancer Institute at Providence Saint John’s Health Center
- Garni Barkhoudarian
- Pacific Neuroscience Institute, John Wayne Cancer Institute at Providence Saint John’s Health Center
- John R. Jalas
- Department of Pathology, Providence Saint John’s Health Center
- James S. Wilmott
- Melanoma Institute Australia, The University of Sydney
- Parvinder Hothi
- Ben & Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute
- Xiaowen Wang
- Department of Translational Molecular Medicine, John Wayne Cancer Institute at Providence Saint John’s Health Center
- Yuki Takasumi
- Department of Pathology, Providence Saint John’s Health Center
- Michael E. Buckland
- Department of Neuropathology, Royal Prince Alfred Hospital, the Brain and Mind Centre, The University of Sydney
- John F. Thompson
- Melanoma Institute Australia, The University of Sydney
- Georgina V. Long
- Melanoma Institute Australia, The University of Sydney
- Charles S. Cobbs
- Ben & Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute
- Ilya Shmulevich
- Institute for Systems Biology
- Daniel F. Kelly
- Pacific Neuroscience Institute, John Wayne Cancer Institute at Providence Saint John’s Health Center
- Richard A. Scolyer
- Melanoma Institute Australia, The University of Sydney
- Dave S. B. Hoon
- Department of Translational Molecular Medicine, John Wayne Cancer Institute at Providence Saint John’s Health Center
- Diego M. Marzese
- Department of Translational Molecular Medicine, John Wayne Cancer Institute at Providence Saint John’s Health Center
- DOI
- https://doi.org/10.1038/s41467-018-06715-y
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
The treatment of brain metastases is often limited by the ability to diagnose their origins. Here the authors generate DNA methylomes from the three most frequent types of brain metastases, identify epigenetic signatures specific to each type of metastasis and construct a DNA methylation-based classifier (BrainMETH) to advance brain metastasis diagnosis.
