Hematology Reports (May 2012)

A case of cutaneous large B-cell lymphoma of the legs appearing as chronic venous ulceration

  • Alfredo Rossi,
  • Giorgia Cortesi,
  • Claudia Abruzzese,
  • Diego Orsini,
  • Gabriella De Marco,
  • Alessanrdra Narcisi,
  • Marta Carlesimo

DOI
https://doi.org/10.4081/hr.2012.e6
Journal volume & issue
Vol. 4, no. 2
pp. e6 – e6

Abstract

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We report here a case of a woman with a cutaneous large B-cell lymphoma of the legs. She had a plaque lesion, superficially ulcerated and necrotized with tumorous borders situated on the posterior side of the right leg and two red or bluish-red nodular lesions. A skin biopsy from both nodular and plaque lesion showed a diffuse infiltrate of atypical large B cells CD20+ and CD79a+, spanning epidermis, dermis and subcutaneous tissue. A therapeutic approach containing anti-CD20 monoclonal antibody (rituximab) was suggested.

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