Einstein (São Paulo) ()

Nosocomial infections by Klebsiella pneumoniae carbapenemase producing enterobacteria in a teaching hospital

  • Gabriela Seibert,
  • Rosmari Hörner,
  • Bettina Holzschuh Meneghetti,
  • Roselene Alves Righi,
  • Nara Lucia Frasson Dal Forno,
  • Adenilde Salla

DOI
https://doi.org/10.1590/s1679-45082014ao3131
Journal volume & issue
Vol. 12, no. 3
pp. 282 – 286

Abstract

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Objective To analyze the profile of patients with microorganisms resistant to carbapenems, and the prevalence of the enzyme Klebsiella pneumoniae carbapenemase in interobacteriaceae. Methods Retrospective descriptive study. From the isolation in bacteriological tests ordered by clinicians, we described the clinical and epidemiological characteristics of patients with enterobacteria resistants to carbapenems at a university hospital, between March and October 2013. Results We included 47 isolated patients in this study, all exhibiting resistance to carbapenems, including 9 patients who were confirmed as infected/colonized with K. pneumoniae carbapenemase. Isolation in tracheal aspirates (12; 25.5%) predominated. The resistance to ertapenem, meropenem, and imipenem was 91.5%, 83.0% and 80.0%, respectively. Aminoglycosides was the class of antimicrobials that showed the highest sensitivity, 91.5% being sensitive to amikacin and 57.4% to gentamicin. Conclusion The K. pneumoniae carbapenemase was an important agent in graun isotaling in hospital intection. The limited therapeutic options emphasize the need for rapid laboratory detection, as well as the implementation of measures to prevent and control the spread of these pathogens.

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