Molecules (Jan 2024)

Investigation into the Influence of the Process Parameters on the Stability of a Poly(Vinyl)-Alcohol-Based Coating System

  • Viviana Claudia Canale,
  • Lorenzo Paleari,
  • Mario Bragaglia,
  • Greta Petrella,
  • Leonardo Severini,
  • Francesca Nanni,
  • Claudia Mazzuca,
  • Antonio Palleschi

DOI
https://doi.org/10.3390/molecules29020386
Journal volume & issue
Vol. 29, no. 2
p. 386

Abstract

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Most tablets put on the market are coated with polymers soluble in water. The Opadry II 85 series from Colorcon Inc., is a family of PVA-based products marketed since the 1990s. Despite numerous publications on the properties of PVA, to date, limited work has been undertaken to determine the physico-chemical parameters (i.e., UV light, high temperature, and relative humidity) that could affect the performance of PVA-based coatings. To this end, we performed artificial ageing processes on samples made of Opadry Orange II or of some selected components of this coating and analysed them by means of a multidisciplinary approach, using, for example, FTIR, NMR, rheology, and DMTA measurements. In this way, we analysed the influence of the critical components of the Opadry Orange II formula, such as titanium dioxide and aluminium hydroxide, on the coating characteristics under ageing conditions.

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