Cancers (Sep 2021)

Light Therapy for Cancer-Related Fatigue in (Non-)Hodgkin Lymphoma Survivors: Results of a Randomized Controlled Trial

  • Daniëlle E. J. Starreveld,
  • Laurien A. Daniels,
  • Jacobien M. Kieffer,
  • Heiddis B. Valdimarsdottir,
  • Jessie de Geus,
  • Mirthe Lanfermeijer,
  • Eus J. W. van Someren,
  • G. Esther A. Habers,
  • Jos A. Bosch,
  • Cécile P. M. Janus,
  • Dick Johan van Spronsen,
  • Roel J. de Weijer,
  • Erik W. A. Marijt,
  • Eva de Jongh,
  • Josée M. Zijlstra,
  • Lara H. Böhmer,
  • Margreet Houmes,
  • Marie José Kersten,
  • Catharina M. Korse,
  • Huub H. van Rossum,
  • William H. Redd,
  • Susan K Lutgendorf,
  • Sonia Ancoli-Israel,
  • Flora E. van Leeuwen,
  • Eveline M. A. Bleiker

DOI
https://doi.org/10.3390/cancers13194948
Journal volume & issue
Vol. 13, no. 19
p. 4948

Abstract

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Purpose: To evaluate the short- and long-term effects of light therapy on fatigue (primary outcome) and sleep quality, depression, anxiety, quality of life, and circadian rhythms (secondary outcomes) in survivors of (non-)Hodgkin lymphoma presenting with chronic cancer-related fatigue. Methods: We randomly assigned 166 survivors (mean survival 13 years) to a bright white light intervention (BWL) or dim white light comparison (DWL) group. Measurements were completed at baseline (T0), post-intervention (T1), at three (T2), and nine (T3) months follow-up. A mixed-effect modeling approach was used to compare linear and non-linear effects of time between groups. Results: There were no significant differences between BWL and DWL in the reduction in fatigue over time. Both BWL and DWL significantly (p T0-T1 = −0.71; EST1-T3 = 0.15). Similar results were found for depression, sleep quality, and some aspects of quality of life. Light therapy had no effect on circadian rhythms. Conclusions: BWL was not superior in reducing fatigue compared to DWL in HL and DLBCL survivors. Remarkably, the total sample showed clinically relevant and persistent improvements on fatigue not commonly seen in longitudinal observational studies in these survivors.

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